The Efficacy of Antiviral Medications in Managing Blood Oxygen Levels in Covid-19 Patients Afflicted by Chronic Kidney Conditions

Fendy Prasetyawan; Faisal Akhmal  Muslikh; Anis Akhwan  Dhafin; Elsa Mahardika  Putri; Yuneka  Saristiana; Susilo Margining  Raharjo

doi:10.55927/cjas.v1i1.7030

Authors

Fendy Prasetyawan Universitas Kadiri
Faisal Akhmal Muslikh Institut Ilmu Kesehatan Bhakti Wiyata
Anis Akhwan Dhafin Universitas Kadiri
Elsa Mahardika Putri Universitas Kadiri
Yuneka Saristiana Universitas Kadiri
Susilo Margining Raharjo Universitas Kadiri

DOI:

https://doi.org/10.55927/cjas.v1i1.7030

Keywords:

Blood, patients, Covid-19

Abstract

This research assesses the efficacy and safety of employing antiviral drugs in individuals with COVID-19 and chronic kidney disease. The study results reveal a reduced effectiveness of the drug in enhancing oxygen saturation in patients, as indicated by a p-value of 0.026 for SpO2. Consequently, the administration of antiviral drugs to individuals with chronic kidney disease warrants careful consideration. Moreover, there is a need to pay attention to the safety aspects of antiviral drug utilization, particularly with a p-value of 0.026 for Clcr. It is advisable to refrain from using specific antiviral drugs, such as favipiravir, in COVID-19 patients with chronic kidney conditions. However, contemplating the use of remdesivir at an appropriate dosage may be viable if the patient's glomerular filtration rate (GFR) exceeds 30 ml/minute. The study's conclusion underscores the significance of meticulous and personalized management when employing antiviral drugs in COVID-19 patients with chronic kidney disease. A comprehensive consideration of factors such as effectiveness, safety, and the patient's renal health is imperative to ensure an optimal and tailored treatment approach.

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