Formula Development and Characterization Testing of Niacinamide Nano Liposomes as Anti Aging

Fitri Jaya Santi Utami Dewi; Ilham Kuncahyo; T.N Saifullah

doi:10.55927/fjmr.v3i9.11223

Authors

Fitri Jaya Santi Utami Dewi Department of Pharmacy, Faculty of Pharmacy, Setia budi University, Surakarta
Ilham Kuncahyo Department of Pharmacy, Faculty of Pharmacy, Setia budi University, Surakarta
T.N Saifullah Department of Pharmacy, Faculty of Pharmacy, Setia budi University, Surakarta

DOI:

https://doi.org/10.55927/fjmr.v3i9.11223

Keywords:

Niacinamide Optimization, Liposomes, Phosphatidylcholine, Cholesterol, Anti-aging Activity, Simplex Lattice Design

Abstract

Niacinamide has a mechanism of action as an anti-aging agent by increasing fibroblast production by stimulating collagen synthesis and can increase elastin which can prevent wrinkles on the skin of the facial area. The most commonly used method is thin layer hydration followed by sonication. Determination of the optimum formula using expert design with the simplex lattice design method. The purpose of the study was to determine the effect of Phosphatidylcholine concentration of 0.5-5% and Cholesterol concentration of 0.3-5% on the physical properties of niacinamide liposomes, obtain the optimal formula for nano liposomes niacinamide and determine the anti-aging activity of Niacinamide liposomes tested on the backs of rabbits. In the simplex lattice design method, the optimal formula of Phosphotidylcholine with a concentration of 4.7% and cholesterol with a concentration of 0.3% was obtained which produced nanoliposome characteristics including particle size of 135.7 zeta potential -77.19, Adsorption Efficiency of 98.01% and has anti -aging activity with parameters increasing collagen 29.98% and elasticity 65.56%. Niacinamide preparations provide a large increase in anti-aging activity and increase permeability so that they can provide a faster effect than niacinamide serum without liposomes.

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