Overview of Related Features of Viral Hepatitis: From Pathogenesis to Prevention, Treatment, and Complications
DOI:
https://doi.org/10.55927/fjmr.v2i5.4321Keywords:
Viral Hepatitis, Pathogenesis, Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis D, Hepatitis E, Liver Cir-rhosis, Hepatocellular CarcinomaAbstract
EnglishViral hepatitis is a significant global health issue with multiple aspects that require attention. This article will provide an overview of the discussions on viral hepatitis, including pathogenesis, serologic markers, prevention and treatment strategies, and complications or sequelae associated with hepatitis A, B, C, D, and E. The pathogenesis section explores the distinct mechanisms of viral entry, replication, and immune response for each hepatitis virus, highlighting the importance of understanding these processes for targeted therapies and preventive measures. Serologic markers play a crucial role in the diagnosis of viral hepatitis, and their detection enables accurate diagnosis, differentiation of acute and chronic infections, and assessment of disease progression and treatment response. Prevention strategies, such as vaccination, safe injection practices, blood and organ screening, and safe sex practices, are essential for reducing the transmission and burden of viral hepatitis. Treatment strategies, including antiviral therapy and supportive care, are discussed for the management of chronic hepatitis and associated complications.
Downloads
References
Stanaway JD, Flaxman AD, Naghavi M, et al. The global burden of viral hepati-tis from 1990 to 2013: findings from the Global Burden of Disease Study 2013. Lancet. 2016;388(10049):1081-1088. doi: 10.1016/S0140-6736(16)30579-7
Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and ende ic ty. Vaccine. 2012;30(12):2212 2219. doi: 10.1016/j.vaccine.2011.12.116
Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology. 2013;57(4):1333-1342. doi: 10.1002/hep.26141
Wedemeyer H, Manns MP. Epidemiology, pathogenesis and management of hepatitis D: update and challenges ahead. Nat Rev Gastroenterol Hepatol. 2010;7(1):31-40. doi: 10.1038
Aggarwal R. Clinical and epidemiological aspects of hepatitis E. Indian J Gas-troenterol. 2012;31(2):59-62. doi: 10.1007/s12664-012-0202-4
World Health Organization. (2019). Global Hepatitis Report, 2017. Retrieved from https://apps.who.int/iris/bitstream/handle/10665/255016/9789241565455-eng.pdf
World Health Organization. (2020). Hepatitis A Fact Sheet. Retrieved from https://www.who.int/news-room/fact-sheets/detail/hepatitis-a
World Health Organization. (2020). Hepatitis B Fact Sheet. Retrieved from https://www.who.int/news-room/fact-sheets/detail/hepatitis-b
World Health Organization. (2021). Hepatitis C Fact Sheet. Retrieved from https://www.who.int/news-room/fact-sheets/detail/hepatitis-c
World Health Organization. (2020). Hepatitis D Fact Sheet. Retrieved from https://www.who.int/news-room/fact-sheets/detail/hepatitis-d
World Health Organization. (2020). Hepatitis E Fact Sheet. Retrieved from https://www.who.int/news-room/fact-sheets/detail/hepatitis-e
Lemon SM, et al. Hepatitis A Virus. In: Knipe DM, Howley PM, eds. Fields Vi-rology. 6th edition. Philadelphia, PA: Lippincott Williams & Wilkins; 2013: 799-840.13. Lok AS, McMahon BJ. Chronic hepatitis B: update 2009. Hepatology.2009
Terrault NA, Lok ASF, McMahon BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018;67(4):1560-1599.
World Health Organization. Hepatitis C Fact Sheet. 2021. https://www.who.int/news-room/fact-sheets/detail/hepatitis-c.
Gupta E, Agarwala P, Kumar G, et al. Extrahepatic manifestations of hepatitis A: a comprehensive review. Ann Gastroenterol. 2018
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Ronald P. Cabral, M.D, Rachelle C. Gutierrez, MLT

This work is licensed under a Creative Commons Attribution 4.0 International License.




























