The Effectiveness of Using Per Rectal Oxytocin Drip and Misoprostol on the Amount of Bleeding in Post Partum Sectio Caesarea

Lisa  Rosalina; Hilda; Rosalin Ariefah  Putri

doi:10.55927/fjst.v2i3.2906

Authors

Lisa Rosalina Poltekkes Kemenkes Kaltim
Hilda Poltekkes Kemenkes Kaltim
Rosalin Ariefah Putri Poltekkes Kemenkes Kaltim

DOI:

https://doi.org/10.55927/fjst.v2i3.2906

Keywords:

Oxytocin, Misoprostol, Bleeding

Abstract

This study aims to determine the effectiveness of using oxytocin drip and misoprostol rectally on the amount of bleeding in post partum sectio caesarea. The research design used in this study was a quasy experiment with a two group posttest design. The study population was post section caesarea mothers who were given the drug misoprostol plus oxytocin drip and oxytocin alone taken from September to November as many as 242. The sampling technique used was accidental sampling and used the slovin formula so that the sample in this study was 72 respondents. The hypothesis test in this study used a parametric statistical test, namely the Independent T-Test. Based on the research results, it can be concluded that oxytocin drip and per rectal misoprostol are effective against bleeding in post partum sectio caesarea mothers with a p-value of 0.000 (<0.05).

Downloads

Download data is not yet available.

References

A.Fahira Nur , Abd. Rahman, H. K. (2019). Faktor Risiko Kejadian Perdarahan Postpartum Di Rumah Sakit Umum (Rsu) Anutapura Palu. Jurnal Kesehatan Tadulako, 5(1), 26–31.

Adnan, N., Conlan-Trant, R., Mccormick, C., Boland, F., & Murphy, D. J. (2018). Intramuscular versus intravenous oxytocin to prevent postpartum haemorrhage at vaginal delivery: randomised controlled trial. BMJ Open. http://doi.org/10.1136/bmj.k3546

Alanazi, R., Alotaibi, M., & Djouhri, L. (2018). In vitro effects of hydrogen peroxide on rat uterine contraction before and during pregnancy. Croatian Medical Journal, 59(6), 327–334. http://doi.org/10.3325/cmj.2018.59.327

Alotaibi, M. F. (2019). Effects of Intermittent and Continuous Oxytocin Exposure on Myometrial Contractile Activity in Term-Pregnant Rats In Vitro. Reproductive Sciences. http://doi.org/10.1007/s43032-019-00104-6

Ambounda, N. L., Woromogo, S. H., Yagata-Moussa, F. E., Ossouka, L. A. O., Tekem, V. N. S., Ango, E. O., & Kouanang, A. J. (2021). Primary postpartum haemorrhage at the Libreville University Hospital Centre: Epidemiological profile of women. PLoS ONE. http://doi.org/10.1371/journal.pone.0257544

Duffield, A., Mckenzie, C., Carvalho, B., Ramachandran, B., Yin, V., El-Sayed, Y. Y., … Butwick, A. J. (2018). The Effect of a High rate vs. a Low rate Oxytocin Infusion for Maintaining Uterine Contractility during Elective Cesarean Delivery: A Prospective Randomized Clinical Trial. HHS Public Access. http://doi.org/10.1213/ANE.0000000000001658

Escobar, M. F., Nassar, A. H., Theron, G., Barnea, E. R., Nicholson, W., … Wright, A. (2022). FIGO recommendations on the management of postpartum hemorrhage 2022. International Journal of Gynecology & Obstetrics, 157(S1), 3–50. http://doi.org/10.1002/ijgo.14116

Geller, S. E., Koch, A. R., Garland, C. E., MacDonald, E. J., Storey, F., & Lawton, B. (2018). A global view of severe maternal morbidity: Moving beyond maternal mortality. Reproductive Health, 15(Suppl 1). http://doi.org/10.1186/s12978-018-0527-2

Geni, P. L., Rachman, I. T., & Pradjatmo, H. (2017). Peran Penambahan Misoprostol Pada Penatalaksanaan Aktif Kala III Dalam Menurunkan Perdarahan Pascapersalinan. Jurnal Kesehatan Reproduksi, 4(3), 170–177.

Hawker, L., & Weeks, A. (2020). Postpartum haemorrhage (PPH) rates in randomized trials of PPH prophylactic interventions and the effect of underlying participant PPH risk: A meta-analysis. BMC Pregnancy and Childbirth, 20(1), 1–13. http://doi.org/10.1186/s12884-020-2719-3

Kim, S.-C., Lee, J.-E., Kang, S. S., Yang, H.-S., Kim, S. S., & An, B.-S. (2017). The expression of oxytocin and oxytocin receptor The regulation of oxytocin and oxytocin receptor in human placenta according to gestational age. Journal of Molecular Endocrinology Seung-Chul. http://doi.org/10.1530/JME-16-0223

Kristianingsih, A., Mukhlis, H., & Ermawati, E. (2020). Faktor-faktor yang berhubungan dengan kejadian perdarahan postpartum di RSUD Pringsewu. Journal Wellnes, 2(February), 309–313. Retrieved from https://wellnes.journalpress.id/wellnes

Malhotra, S., Kaur, D., Bhatia, K., Kumar, M., & Renjhen, P. (2016). Role of Anaesthesiologist in Management of PPH, 4, 3612–3623. http://doi.org/10.21276/sjams.2016.4.10.15

Milhan, M., Soejoenoes, A., & Prawitasari, S. (2019). Efikasi Misoprostol Rektal Intraoperasi Seksio Cesarea Versus Oksitosin dalam Mengurangi Jumlah Perdarahan untuk Mencegah Perdarahan Post Partum. Jurnal Kesehatan Reproduksi, 6(2), 37. http://doi.org/10.22146/jkr.48773

Mohta, M., Chowdhury, R. B., Tyagi, A., & Agarwal, R. (2021). Efficacy of different infusion rates of oxytocin for maintaining uterine tone during elective caesarean section. Anaesthesia and Intensive Care. http://doi.org/10.1177/0310057X20984480

Natalina, Nursari Abdul Syukur , Faridah Hariyani, Dwi Hendriani, R. N. (2017). Hubungan Kadar Hemoglobin Dengan Perdarahan Post Partum Di Rsud Abdul Wahab Sjahranie Samarinda. Mahakam Midwifery Journal, 2(2), 122–133.

Numfor, E., Fobellah, N. N., Tochie, J. N., Njim, T., & Ndesso, S. A. (2020). Oxytocin Versus Misoprostol Plus Oxytocin in the Prevention of Postpartum Hemorrhage at a Semi-Urban Hospital in sub-Saharan Africa: A Retrospective Cohort Study. International Journal of Maternal and Child Health and AIDS (IJMA), 9(3), 287–296. http://doi.org/10.21106/ijma.365

Prata, N., & Weidert, K. (2017). Efficacy of misoprostol for the treatment of postpartum hemorrhage: Current knowledge and implications for health care planning. International Journal of Women’s Health, 8, 341–349. http://doi.org/10.2147/IJWH.S89315

Sammut, M., Sammut, E., Chetcuti, S., & Calleja-Agius, J. (2018). The Role of Oxytocyn.

Satriyandari, Y., & Hariyati, N. R. (2017). Faktor-Faktor Yang Mempengaruhi Kejadian Perdarahan Postpartum. JHeS (Journal of Health Studies), 1(1), 49–64. http://doi.org/10.31101/jhes.185

Sirait, B. I. (2017). Penanganan Perdarahan Post Partum. Prosiding Seminar Nasional Penatalaksanaan Kegawatdaruratan Berbagai Disiplin Ilmu Kedokteran, 53(9), 1689–1699.

Sugiyono. (2016a). Buku Metode Penelitian Manajemen. (Setyawarni, Ed.) (2nd ed.). Bandung: Alfabeta.

Sugiyono. (2016b). Cara mudah Menyusun: Skripsi, Thesis, Disertasi. Alfabeta.

Sugiyono;, P. D. (2013). Metode Penelitian Pendidikan Pendekatan Kuantitatif, Kualitatif dan R&D.

Teesing, G. R., Richardus, J. H., Nieboer, D., Petrignani, M., Erasmus, V., Verduijn-Leenman, A., … Voeten, H. A. C. M. (2020). The effect of a hand hygiene intervention on infections in residents of nursing homes: a cluster randomized controlled trial. BMC Health Services Research. http://doi.org/10.1186/s13756-021-00946-3

Vogel, J. P., Williams, M., Gallos, I., Althabe, F., & Oladapo, O. T. (2019). WHO recommendations on uterotonics for postpartum haemorrhage prevention: What works, and which one? BMJ Global Health, 4(2), 1–6. http://doi.org/10.1136/bmjgh-2019-001466

Wahyuni, C. (2018). Farmakologi Kebidanan. Egc.

WHO. (2018). WHO recommendations for the prevention of postpartum haemorrhage. Geneva, Switzerland: Author.

WHO. (2019). Maternal mortality. Retrieved December 16, 2021, from https://www.who.int/news-room/fact-sheets/detail/maternal-mortality

Widmer, M., Piaggio, G., Nguyen, T. M. H., Osoti, A., Owa, O. O., Misra, S., … Gülmezoglu, A. M. (2018). Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth. New England Journal of Medicine, 379(8), 743–752. http://doi.org/10.1056/NEJMOA1805489/SUPPL_FILE/NEJMOA1805489_DISCLOSURES.PDF

Wolfe, S. A., & Pedowitz, P. (2017). Clinical Management Guidelines for Obstetrician–Gynecologists. American Journal of Obstetrics and Gynecology, 130(1). http://doi.org/10.1016/0002-9378(47)90452-3

Yo, E. C., Alifian, M., Putra, R., & Phowira, J. (2020). Integrasi Misoprostol dalam Daftar Obat Esensial Nasional sebagai Alternatif Penanganan Perdarahan Pasca-Persalinan di Wilayah Pedesaan di Indonesia. CDK, 47(8), 27–30.