Physiological Changes in Mother During Pregnancy that Impact on the Pharmacokinetics and Pharmacodynamic of Drug: Literature Review

Jesviekha Ardriani  Maulana; Jesy  Fatimah

doi:10.55927/fjst.v2i7.5186

Authors

Jesviekha Ardriani Maulana Program Studi Sarjana Terapan Kebidanan Universitas Indonesia Maju
Jesy Fatimah Program Studi Sarjana Terapan Kebidanan Universitas Indonesia Maju

DOI:

https://doi.org/10.55927/fjst.v2i7.5186

Keywords:

Physiological Changes, Pharmacokinetics, Pharmacodynamics, Pregnancy

Abstract

Physiological changes occurring during pregnancy can affect drug pharmacodynamics and pharmacokinetics, leading to decreased or increased drug disposition. This research uses a systematic review method or literature review. The analysis was carried out by collecting data that met the requirements and filtering based on the suitability of the article title with the research objectives to obtain relevant articles after going through the filtering stage to data extraction. The results showed that physiological changes in pregnancy induce major changes in the pharmacokinetic properties of many drugs. These changes affect the distribution, absorption, metabolism, and excretion of drugs, and thus may affect their pharmacodynamic properties during pregnancy.

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References

Ansari, J., Carvalho, B., Shafer, S. L., & Flood, P. (2016). Pharmacokinetics and pharmacodynamics of drugs commonly used in pregnancy and parturition. Anesthesia & Analgesia, 122(3), 786-804.

Asri, R. C., & Annisa, S. E. (2023). Prevalensi Kelainan Kulit pada Masa Kehamilan. INSOLOGI: Jurnal Sains dan Teknologi, 2(3), 633-642.

Coppola, P., Kerwash, E., Nooney, J., Omran, A., & Cole, S. (2022). Pharmacokinetic data in pregnancy: a review of available literature data and important considerations in collecting clinical data. Frontiers in Medicine, 9, 940644.

Costantine, M. M. (2014). Physiologic and pharmacokinetic changes in pregnancy. Frontiers in pharmacology, 5, 65.

Darakjian, L. I., & Kaddoumi, A. (2019). Physiologically based pharmacokinetic/pharmacodynamic model for caffeine disposition in pregnancy. Molecular pharmaceutics, 16(3), 1340-1349.

Eke, A. C., Gebreyohannes, R. D., Fernandes, M. F. S., & Pillai, V. C. (2023). Physiologic Changes During Pregnancy and Impact on Small‐Molecule Drugs, Biologic (Monoclonal Antibody) Disposition, and Response. The Journal of Clinical Pharmacology, 63, S34-S50.

Febriati, L. D., & Zakiyah, Z. (2022). Hubungan Dukungan Keluarga Dengan Adaptasi Perubahan Psikologi Pada Ibu Hamil. Jurnal Kebidanan Indonesia, 13(1).

I., Irawan, M. P., & Azhari, S. F. (2021). Gambaran Leukosit pada Sedimen Urine Ibu Hamil. Jurnal Penelitian Perawat Profesional, 3(3), 541-548.

Kazma, J. M., van den Anker, J., Allegaert, K., Dallmann, A., & Ahmadzia, H. K. (2020). Anatomical and physiological alterations of pregnancy. Journal of pharmacokinetics and pharmacodynamics, 47(4), 271-285.

Lestari, L. (2023). Pemeriksaan Hemoglobin Dan Pemberian Tablet Fe Pada Ibu Hamil Tm Iii Di Puskesmas Teluk Bogam. Pengabdian Masyarakat, 1(2), 18-21.

Mardliyana, N. E., & Rullyansyah, S. (2022). Farmakologi Kebidanan. Rena Cipta Mandiri.

Paleari, R., Vidali, M., Ceriotti, F., Pintaudi, B., De Angelis, M. L., Vitacolonna, E., ... & Mosca, A. (2023). Reference intervals for glycated albumin during physiological pregnancy of Europid women: Evidences from a prospective observational study. Clinica Chimica Acta, 541, 117246.

Pratama, T. P. I. R. N., & Indriastuti, N. A. (2023). Efektivitas Prenatal Yoga Untuk Mengurangi Nyeri Punggung Pada Ibu Hamil Trimester III. DIAGNOSA: Jurnal Ilmu Kesehatan dan Keperawatan, 1(2), 112-121.

Shuster, Diana L., Laura M. Shireman, Xiaosu Ma, Danny D. Shen, Shannon K. Flood Nichols, Mahmoud S. Ahmed, Shannon Clark et al. "Pharmacodynamics of metformin in pregnant women with gestational diabetes mellitus and nonpregnant women with type 2 diabetes mellitus." The Journal of Clinical Pharmacology 60, no. 4 (2020): 540-549

Uyun, Y., Apsari, R. K. F., & Suharso, P. H. Manajemen Anestesi Pada Seksio Sesarea Pada Pasien Covid-19 Derajat Berat. Jurnal Komplikasi Anestesi, 8(3), 9-17.

W Witari, N. N. D., & Dewianti, N. M. (2019). Perbedaan Pengetahuan Ibu Hamil Trimester I Setelah Diberikan Self Management Education Menghadapi Emesis Gravidarum Di BPM Wilayah Kerja Puskesmas IV Denpasar Selatan: Differences Knowledge Of Pregnant Women In First Trimester After Being Given Self Management Education Facing Emesis Gravidarum At Private Practice Midwives Puskesmas Iv Denpasar Selatan. Bali Medika Jurnal, 6(2), 198-204. http://www.journal.ppnijateng.org/index.php/j ikj/article/view/1054

Wuysang, A. D., & Hammado, N. (2022). Tatalaksana Nyeri Kanker Pada Kehamilan.