The Relationship between Hyperuricemia and Hypertension in Internal Medicine Policlinic Patients in RSUD Dr. Soetomo 2019-2021

Authors

  • Muhammad Ghifary Mahindisyah Universitas Airlangga Surabaya
  • Ira Humairah Universitas Airlangga Surabaya
  • Artaria Tjempakasari Universitas Airlangga Surabaya
  • Lilik Herawati Universitas Airlangga Surabaya

DOI:

https://doi.org/10.55927/fjst.v3i1.7654

Keywords:

Hyperuricemia, Hypertension, Uric Acid, Cardiovascular, Blood Pressure

Abstract

Hypertension was characterized by persistently high blood pressure in the systemic arteries.  This typed of researched was descriptive retrospective with consecutive sampling used inclusion and exclusion criteria. Data analysis used the Skewness and Kurtosis Normality Test and Chi Square Test with p<0,05.  The results of the studied showed that 42 people was found with a population percentage of 67,7% who was known to had hyperuricemia with hypertension. There was a significant relationship between the incidence of hyperuricemia and the incidence of hypertension with a valued of p=0,003 (p<0,05).  The odds ratio (OR) valued in this study was 8,17, meaning that patients with hyperuricemia had an 8,17 times greater chance of suffering from hypertension compared to patients without hyperuricemia. It was recommended that further research use case control studies or cohort studies to find out which variables are the cause and effect between hyperuricemia and hypertension.

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References

Alqarni, N. A., & Hassan, A. H. (2018). Knowledge and practice in the management of asymptomatic hyperuricemia among primary health care physicians in Jeddah, Western Region of Saudi Arabia. Saudi medical journal, 39(12), 1218–1225. https://doi.org/10.15537/smj.2018.12.23715

Aminullah A, Rukman Y, Munasir Z, Sastroasmoro S. (2007). Variabel dan Hubungan antar Variabel. In: Sastroasmoro S dan Ismael S (ed). Dasar – Dasar Metodologi Penelitian Klinis Edisi Ketiga. Jakarta: Sagung Seto, pp: 255-78.

Ann A, Erwinanto, Rosana B, Antonia A, Nani H, Lukito AA, et al. (2015). Pedoman tatalaksana hipertensi pada penyakit kardiovaskular. Edisi ke-1. Jakarta: Perhimpunan Dokter Spesialis Kardiovaskular Indonesia.

Barkas, F., Elisaf, M., Liberopoulos, E., Kalaitzidis, R., & Liamis, G. (2018). Uric acid and incident chronic kidney disease in dyslipidemic individuals. Current medical research and opinion, 34(7), 1193–1199. https://doi.org/10.1080/03007995.2017.1372157

Benn, C. L., Dua, P., Gurrell, R., Loudon, P., Pike, A., Storer, R. I., & Vangjeli, C. (2018). Physiology of Hyperuricemia and Urate-Lowering Treatments. Frontiers in medicine, 5, 160. https://doi.org/10.3389/fmed.2018.00160

Bjerre, H. L., Christensen, J. B., Buus, N. H., Simonsen, U., & Su, J. (2019). The role of aliskiren in the management of hypertension and major cardiovascular outcomes: a systematic review and meta-analysis. Journal of human hypertension, 33(11), 795–806. https://doi.org/10.1038/s41371-018-0149-8

Blood Pressure Lowering Treatment Trialists' Collaboration (2014). Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet (London, England), 384(9943), 591–598. https://doi.org/10.1016/S0140-6736(14)61212-5

Bove, M., Cicero, A. F. G., Veronesi, M., & Borghi, C. (2017). An evidence-based review on urate-lowering treatments: implications for optimal treatment of chronic hyperuricemia. Vascular Health and Risk Management, Volume 13, 23–28. https://doi.org/10.2147/VHRM.S115080

Brand, F. N., McGee, D. L., Kannel, W. B., Stokes, J., 3rd, & Castelli, W. P. (1985). Hyperuricemia as a risk factor of coronary heart disease: The Framingham Study. American journal of epidemiology, 121(1), 11–18. https://doi.org/10.1093/oxfordjournals.aje.a113972

Cannon, P. J., Stason, W. B., Demartini, F. E., Sommers, S. C., & Laragh, J. H. (1966). Hyperuricemia in primary and renal hypertension. The New England journal of medicine, 275(9), 457–464. https://doi.org/10.1056/NEJM196609012750902

Chen, C., Lü, J. M., & Yao, Q. (2016). Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview. Medical science monitor : international medical journal of experimental and clinical research, 22, 2501–2512. https://doi.org/10.12659/msm.899852

Dominiczak, A., Delles, C., & Padmanabhan, S. (2017). Genomics and Precision Medicine for Clinicians and Scientists in Hypertension. Hypertension (Dallas, Tex.: 1979), 69(4), e10–e13. https://doi.org/10.1161/HYPERTENSIONAHA.116.08252

Ehret, G. B., Ferreira, T., Chasman, D. I., Jackson, A. U., Schmidt, E. M., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, L. A., Kanoni, S., Petersen, A. K., Pihur, V., Strawbridge, R. J., Shungin, D., Hughes, M. F., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S., … Munroe, P. B. (2016). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature genetics, 48(10), 1171–1184. https://doi.org/10.1038/ng.3667

Ettehad, D., Emdin, C. A., Kiran, A., Anderson, S. G., Callender, T., Emberson, J., Chalmers, J., Rodgers, A., & Rahimi, K. (2016). Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet (London, England), 387(10022), 957–967. https://doi.org/10.1016/S0140-6736(15)01225-8

Eun, Y., Kim, I. Y., Han, K., Lee, K. N., Lee, D. Y., Shin, D. W., Kang, S., Lee, S., Cha, H. S., Koh, E. M., Lee, J., & Kim, H. (2021). Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women. Arthritis research & therapy, 23(1), 304. https://doi.org/10.1186/s13075-021-02701-w

Fagard, R., Brguljan, J., Staessen, J., Thijs, L., Derom, C., Thomis, M., & Vlietinck, R. (1995). Heritability of conventional and ambulatory blood pressures. A study in twins. Hypertension (Dallas, Tex. : 1979), 26(6 Pt 1), 919–924. https://doi.org/10.1161/01.hyp.26.6.919

Grassi, D., Ferri, L., Desideri, G., di Giosia, P., Cheli, P., del Pinto, R., Properzi, G., & Ferri, C. (2013). Chronic Hyperuricemia, Uric Acid Deposit and Cardiovascular Risk. Current Pharmaceutical Design, 19(13), 2432–2438. https://doi.org/10.2174/1381612811319130011

Graves J. W. (2000). Management of difficult-to-control hypertension. Mayo Clinic proceedings, 75(3), 278–284. https://doi.org/10.4065/75.3.278.

Harrison D. G. (2013). The mosaic theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension. Journal of the American Society of Hypertension : JASH, 7(1), 68–74. https://doi.org/10.1016/j.jash.2012.11.007

Janssen, C. A., Jansen, T. L. T. A., Oude Voshaar, M. A. H., Vonkeman, H. E., & van de Laar, M. A. F. J. (2017). Quality of care in gout: a clinical audit on treating to the target with urate lowering therapy in real-world gout patients. Rheumatology international, 37(9), 1435–1440. https://doi.org/10.1007/s00296-017-3777-3

Johnson, R. J., Bakris, G. L., Borghi, C., Chonchol, M. B., Feldman, D., Lanaspa, M. A., Merriman, T. R., Moe, O. W., Mount, D. B., Sanchez Lozada, L. G., Stahl, E., Weiner, D. E., & Chertow, G. M. (2018). Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation. American journal of kidney diseases : the official journal of the National Kidney Foundation, 71(6), 851–865. https://doi.org/10.1053/j.ajkd.2017.12.009

Kaishusha, David Salama, Philippe Bianga Katchunga. (2014). Study on the relationship between hypertension and hyperuricemia in a group of patient in South Kivu, democratic republic of Congo. Journal of Clinical & Experimental Cardiology. April;5(3).

Kementerian Kesehatan RI. (2019). Laporan Nasional Riskesdas 2018/ Badan Penelitian dan Pengembangan Kesehatan. Jakarta: Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan.

Kuwabara M. (2016). Hyperuricemia, Cardiovascular Disease, and Hypertension. Pulse (Basel, Switzerland), 3(3-4), 242–252. https://doi.org/10.1159/000443769

Kuwabara, M. (2015). Hyperuricemia, Cardiovascular Disease, and Hypertension. Pulse, 3(3–4), 242–252. https://doi.org/10.1159/000443769

Kuwabara, M., Niwa, K., Nishi, Y., Mizuno, A., Asano, T., Masuda, K., Komatsu, I., Yamazoe, M., Takahashi, O., & Hisatome, I. (2014). Relationship between serum uric acid levels and hypertension among Japanese individuals not treated for hyperuricemia and hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 37(8), 785–789. https://doi.org/10.1038/hr.2014.75

Liu, N., Xu, H., Sun, Q., Yu, X., Chen, W., Wei, H., Jiang, J., Xu, Y., & Lu, W. (2021). The Role of Oxidative Stress in Hyperuricemia and Xanthine Oxidoreductase (XOR) Inhibitors. Oxidative Medicine and Cellular Longevity, 2021, 1–15. https://doi.org/10.1155/2021/1470380

Loeffler, L. F., Navas-Acien, A., Brady, T. M., Miller, E. R., 3rd, & Fadrowski, J. J. (2012). Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey, 1999-2006. Hypertension (Dallas, Tex. : 1979), 59(4), 811–817. https://doi.org/10.1161/HYPERTENSIONAHA.111.183244

Ma, H. Y., Chen, S., & Du, Y. (2021). Estrogen and estrogen receptors in kidney diseases. Renal failure, 43(1), 619–642. https://doi.org/10.1080/0886022X.2021.1901739

Maiuolo, J., Oppedisano, F., Gratteri, S., Muscoli, C., & Mollace, V. (2016). Regulation of uric acid metabolism and excretion. International journal of cardiology, 213, 8–14. https://doi.org/10.1016/j.ijcard.2015.08.109

Mazzali, M., Kanellis, J., Han, L., Feng, L., Xia, Y. Y., Chen, Q., Kang, D. H., Gordon, K. L., Watanabe, S., Nakagawa, T., Lan, H. Y., & Johnson, R. J. (2002). Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. American journal of physiology. Renal physiology, 282(6), F991–F997. https://doi.org/10.1152/ajprenal.00283.2001

Murti, Bhisma. (2010). Desain dan Ukuran Sampel untuk Penelitian Kuantitatif dan Kualitatif di Bidang Kesehatan. Yogyakarta: Gadjah Mada University Press.

Mustafiza, P. V. (2010). Hubungan antara Hiperurisemia dan Hipertensi.

Nguedia Assob, J. C. (2014). The Relationship between Uric Acid and Hypertension in Adults in Fako Division, SW Region Cameroon. Journal of Nutrition & Food Sciences, 04(01). https://doi.org/10.4172/2155-9600.1000257

Notoatmodjo, S. 2012. Metode Penelitian Kesehatan. Jakarta: PT Rineka Cipta.

Novitasari, A., Setyoko, & Tatius, B. (2016). Hiperuresemia Meningkatkan Risiko Hipertensi. JURNAL KEDOKTERAN, 5(2).

Parati, G., & Esler, M. (2012). The human sympathetic nervous system: its relevance in hypertension and heart failure. European heart journal, 33(9), 1058–1066. https://doi.org/10.1093/eurheartj/ehs041

Perez-Ruiz, F., Dalbeth, N., & Bardin, T. (2015). A Review of Uric Acid, Crystal Deposition Disease, and Gout. Advances in Therapy, 32(1), 31–41. https://doi.org/10.1007/s12325-014-0175-z

Pradono, J., Kusumawardani, N., & Rachmalina, R. (2020). Hipertensi Pembunuh Terselubung Di Indonesia. Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan (LPB).

Ramsay, L., Williams, B., Johnston, G., MacGregor, G., Poston, L., Potter, J., Poulter, N., & Russell, G. (1999). Guidelines for management of hypertension: report of the third working party of the British Hypertension Society. Journal of human hypertension, 13(9), 569–592. https://doi.org/10.1038/sj.jhh.1000917

Richette, P., Doherty, M., Pascual, E., Barskova, V., Becce, F., Castañeda-Sanabria, J., Coyfish, M., Guillo, S., Jansen, T. L., Janssens, H., Lioté, F., Mallen, C., Nuki, G., Perez-Ruiz, F., Pimentao, J., Punzi, L., Pywell, T., So, A., Tausche, A. K., Uhlig, T., … Bardin, T. (2017). 2016 updated EULAR evidence-based recommendations for the management of gout. Annals of the rheumatic diseases, 76(1), 29–42. https://doi.org/10.1136/annrheumdis-2016-209707

Saito, I., Saruta, T., Kondo, K., Nakamura, R., Oguro, T., Yamagami, K., Ozawa, Y., & Kato, E. (1978). Serum uric acid and the renin-angiotensin system in hypertension. Journal of the American Geriatrics Society, 26(6), 241–247. https://doi.org/10.1111/j.1532-5415.1978.tb02396.x

Sastroasmoro, Sudigdo. (2007). Pengukuran dalam Penelitian. In: Sastroasmoro S dan Ismael S (ed). Dasar-Dasar Metodologi Penelitian Klinis Edisi Ketiga. Jakarta: Sagung Seto, pp: 78-91.

Sautin, Y. Y., Nakagawa, T., Zharikov, S., & Johnson, R. J. (2007). Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. American journal of physiology. Cell physiology, 293(2), C584–C596. https://doi.org/10.1152/ajpcell.00600.2006

Stamler, J., Stamler, R., & Neaton, J. D. (1993). Blood pressure, systolic and diastolic, and cardiovascular risks. US population data. Archives of internal medicine, 153(5), 598–615. https://doi.org/10.1001/archinte.153.5.598

Stewart, D. J., Langlois, V., & Noone, D. (2019). Hyperuricemia and Hypertension: Links and Risks. Integrated Blood Pressure Control, Volume 12, 43–62. https://doi.org/10.2147/IBPC.S184685

Sugiyono. (2011). Metode Penelitian Kuantitatif, Kualitatif dan R&D. Bandung:Alfabeta

Thompson, M. D. (2018). Insights in Public Health: Hyperuricemia and Gout in Hawai’i. Hawai’i Journal of Medicine & Public Health : A Journal of Asia Pacific Medicine & Public Health, 77(5), 121–124.

Tumbelaka AR, Riono P, Wirjodiarjo M, Pudjiastuti P, Firman K. (2007). Pemilihan Uji Hipotesis. In: Sastroasmoro S dan Ismael S (ed). Dasar – Dasar Metodologi Penelitian Klinis Edisi Ketiga. Jakarta: Sagung Seto, pp: 279-301.

Turak, O., Ozcan, F., Tok, D., Işleyen, A., Sökmen, E., Taşoğlu, I., Aydoğdu, S., Sen, N., McFann, K., Johnson, R. J., & Kanbay, M. (2013). Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. Journal of clinical hypertension (Greenwich, Conn.), 15(1), 7–13. https://doi.org/10.1111/jch.12026

Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter, N. R., Prabhakaran, D., Ramirez, A., Schlaich, M., Stergiou, G. S., Tomaszewski, M., Wainford, R. D., Williams, B., & Schutte, A. E. (2020). 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension (Dallas, Tex. : 1979), 75(6), 1334–1357. https://doi.org/10.1161/HYPERTENSIONAHA.120.15026

Varagic, J., Ahmad, S., Nagata, S., & Ferrario, C. M. (2014). ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury. Current hypertension reports, 16(3), 420. https://doi.org/10.1007/s11906-014-0420-5

Waring, W. S., Adwani, S. H., Breukels, O., Webb, D. J., & Maxwell, S. R. (2004). Hyperuricaemia does not impair cardiovascular function in healthy adults. Heart (British Cardiac Society), 90(2), 155–159. https://doi.org/10.1136/hrt.2003.016121

Watanabe, S., Kang, D. H., Feng, L., Nakagawa, T., Kanellis, J., Lan, H., Mazzali, M., & Johnson, R. J. (2002). Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension (Dallas, Tex. : 1979), 40(3), 355–360. https://doi.org/10.1161/01.hyp.0000028589.66335.aa

Williams L. A. (2019). The History, Symptoms, Causes, Risk Factors, Types, Diagnosis, Treatments, and Prevention of Gout, Part 2. International journal of pharmaceutical compounding, 23(1), 14–21.

Yang, X., Gu, J., Lv, H., Li, H., Cheng, Y., Liu, Y., & Jiang, Y. (2019). Uric acid induced inflammatory responses in endothelial cells via up-regulating(pro)renin receptor. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 109, 1163–1170. https://doi.org/10.1016/j.biopha.2018.10.129

Yano, H., Tamura, Y., Kobayashi, K., Tanemoto, M., & Uchida, S. (2014). Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease. Clinical and experimental nephrology, 18(1), 50–55. https://doi.org/10.1007/s10157-013-0806-8

Youssef, Magda HM. (2013). Is Hyperuricemia a Risk Factor to Cardiovascular Disease. In: Cairo: Gaze, David C. Ischemic Heart Disease. InTech:123-31.

Yu, M. A., Sánchez-Lozada, L. G., Johnson, R. J., & Kang, D. H. (2010). Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. Journal of hypertension, 28(6), 1234–1242.

Zhao, T., Lv, X., Cao, L., Guo, M., Zheng, S., Xue, Y., Zou, H., Wan, W., & Zhu, X. (2018). Renal excretion is a cause of decreased serum uric acid during acute gout. International journal of rheumatic diseases, 21(9), 1723–1727. https://doi.org/10.1111/1756-185X.13348

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Published

2024-01-08

How to Cite

Mahindisyah, M. G., Humairah, I., Tjempakasari, A., & Herawati, L. (2024). The Relationship between Hyperuricemia and Hypertension in Internal Medicine Policlinic Patients in RSUD Dr. Soetomo 2019-2021. Formosa Journal of Science and Technology, 3(1), 1–26. https://doi.org/10.55927/fjst.v3i1.7654