Dr Skeletal Effects of Soy Isoflavone in Humans: Bone Mineral Density and Bone Markers

Rehan Haider

doi:10.55927/ijis.v2i11.6179

Authors

Rehan Haider University of Karachi

DOI:

https://doi.org/10.55927/ijis.v2i11.6179

Keywords:

Skeletal Effects, Soy Isoflavone, Humans, Bone Mineral Density

Abstract

The potential skeletal effects of soy isoflavones in humans have garnered significant interest owing to their structural resemblance to endogenous estrogen and their potential to impact bone health. This abstract provides a concise overview of the current understanding of the effects of soy isoflavones on bone mineral density (BMD) and bone markers. Numerous studies have investigated the relationship between soy isoflavone consumption and BMD. Some studies have suggested a positive association between soy isoflavone intake and BMD, particularly among postmenopausal women. Isoflavones may exert their effects through estrogen receptor-mediated pathways, potentially mitigating bone loss by reducing osteoclastic activity and promoting osteoblastic functions. However, conflicting results have been reported, with certain studies demonstrating no significant impact on BMD. In addition to BMD, bone markers such as serum osteocalcin, urinary deoxypyridinoline, and tartrate-resistant acid phosphatase have been evaluated to elucidate the mechanistic effects of soy isoflavones on bone metabolism. These markers provide insights into bone turnover, resorption, and formation. Clinical trials have reported mixed findings regarding the influence of soy isoflavones on bone markers, reflecting the complexity of their interaction with bone physiology

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References

Agnusdei, D., Camporeale, A., Zacchei, F., Gennari, C., Baroni, M.C., Costi, D., Biondi, M., Passeri, M., Ciacca, A., Sbrenna, C., Falsettini, E., and Ventura, A., outcomes of ipriflavone on cartilage bulk and cartilage upkeep in sufferers with settled postmenopausal osteoporosis. Curr Ther Res fifty-two: eighty-one–ninety-two, 1992.

Alekel, D. L., Mortillaro, E., Hussain, E. A., West, B., Ahmed, N., Peterson, C. T., Werner, R. Ok., Arjmandi, B. H., and Kukreja, S. C. way of life and natural subscribers to close to leg part cartilage now not natural bulk and elegant stem time in apparent racial groups of premenopausal moms Osteoporos Int 9: 327–338, 1999.

Arjmandi, B.H., The role of phytoestrogens in the stop and state of affairs of osteoporosis in ovarian start manipulation technique imperfection J Am Coll Nutr. 20 (Suppl. 5): 398S–402S, 417S–420S, 2001.

Anderson, J. J. B. Pollitzer, and W. S. Ethnic and ancestral distinctnesses: resistance to osteoporotic fractures Advances in dietary studies, Vol. 9, Ed. Harold H. Draper, Plenum Press, The Big Apple, 1994, lad. 8.

Anderson, J.J.B., and Garner, S.C., Phytoestrogens and Bone Balliere's Clin Endocrinol Metab 12:1–15, 1998. Balliere's Clin Endocrinol Metab 12: 1–15, 1998.

B. L., Khosla, S., and Melton, L. J., III. A whole version for involutional osteoporosis: estrogen imperfection causes type I and type II osteoporosis in postmenopausal mothers and causes cartilage misfortune in developing men. J Bone Miner Res thirteen: 763–773, 1998.

Breslau, N. A., Brinkley, L., Hill, OK. D., and Pak, C. Y. C., dating between animal protein-wealthy diet and type of rock establishment and calcium absorption J Clin Endocrinol Metabol 66: a hundred and forty–146, 1988.

Cauley, J.A., Seeley, D.G., Ensrud, K., Ettinger, B., Black, D., and Cummings, S.R., Estrogen substitute medicinal drug and fractures in in-advance mothers: an examination of the osteoporotic break research group 1995, Ann Intern Med 122: 9–16.

Chen, Y.-M., Ho, S.C., Lam, S.S.H., Ho, S.S.S., and Woo, J.L.F. Soy isoflavones have an excellent effect on bone loss in Chinese-language postmenopausal ladies with decreased bone mass: A double-blind, randomized, controlled trial. J Clin Endocrinol Metab 88: 4740–4747, 2003.

Christiansen, J.S. Johansen, and B.J. Riis, N? haven A/S, Viborg, Denmark, 1987, Pie, J.-E.; Paik, H.Y. The effect of meat protein and soy protein on calcium metabolism in younger grownup Korean women Korean J Nutr 19: 32-40, 1986.

Chin, OK., Evans, M.C., Cornish, J., Cundy, T., and Reid, I.R., differences in chic stem and femoral narrow connector distance in premenopausal wives of Polynesian, Asian, and European origin Osteoporos Int 7: 344–347, 1997

Cooper, C., Campion, G., and Melton, L. J. III. Hip fractures in the elderly: a standard prediction. Osteoporos Int 2: 285–289, 1992.

Cummings, S.R., Nevitt, M.C., Browner, W.S., Stone, OK., Fox, OK.M., Ensrud, OK.E., Cauley, J., Black, D., and Vogt, T.M., chance determinants for stylish fractures in Caucasian moms. examine the osteoporotic rupture studies organization. N Engl J Med 332: 767–773, 1995.

Cummings, S. R.; Melton, L. J., III., Osteoporosis I: Epidemiology and Results of Osteoporotic Fractures, Lancet 359: 1761–1767, 2002.

Cummings, S.R., Cauley, J.A., Palermo, L., Ross, P.D., Wasnich, R.D., Black, D., and Faulkner, K.G. Racial distinctness in fashionable pivot lengths concedes the opportunity to exhibit ethnic distinctness in stylish ruin fees. Osteoporosis Int 4: 226–229, 1994.

Chen, Z., Zheng, W., Custer, L.J., Dai, Q., Shu, X.-O., Jin, F., and Franke, A.A., nutritional use of soy snacks and charm equivalence accompanying the defecation rate of isoflavonoids in adventure excretion samples with Chinese-language daughters in Shanghai. Nutr Most Cancers 33: 82–87, 1999.

De Laet, C.E., Camper Hout, B.A., Burger, H., Hofman, A., and Pols, H.A., Bone mass and hazard of modern-day rupture in human beings interested in something: a pass-localized look, Br Med J 315: 221–225, 1997.

Dallas, F.S., Rice, G.E., Wahlqvist, M.L., Grehan, M., Murkies, A.L., Medley, G., Ayton, R., and Strauss, B.J.G. Consequences of nutritional phytoestrogens in postmenopausal women Climacteric 1: 124–129, 1998.

Delmas, P.D., Eastell, R., Garnero, P., Seibel, M.J., and Stepan, J., Committee of clinical Advisors of the worldwide Osteoporosis foundation the use of biochemical markers of bone turnover in osteoporosis. Osteoporosis Int. 11 (Suppl. 6): S2–17, 2000.

Doren, M., and Samsioe, G. Prevention of postmenopausal osteoporosis accompanying estrogen substitute remedies and joined compounds: renewing dispassionate issues due to the fact 1995. Hum Reprod Update 6: 419–426, 2000.

Davis, J.W., Novotny, R., Wasnich, R.D., and Ross, P.D. Ethnic, anthropometric, and conduct determinants of manual territorial differences in top cartilage bulk Calcif Tissue Int sixty-five: 100–a hundred and five, 1999.

Davis, J.W., Ross, P.D., Nevitt, M.C., and Wasnich, R.D., occurrence of falls among Japanese human beings inquisitive about something in Hawaii J Clin Epidemiol 50: 589–594, 1997.

Eight. Anderson, J. J. B., and Alekel, D. L. Skeletal property of phytoestrogens in humans: cartilage now, not organic bulk, and cartilage indicators Phytoestrogens and Health Eds. Gilani, G.S., and Anderson, J.J.B., American Oil Chemists' Society Press, Champaign, IL, 2002, pp. 341–353.

Family members: K., Lee, E., Kushida, OK., Sartoris, D.J., Ohmura, A., Clopton, P.L., Inque, T. Bone bulk and cloth arrangement at the Pacific Rim: a corresponding middle from points Japan-Born and U.S.-innate Japanese American other halves, J Bone Mineral Res 8: 861–869, 1993

Fleisch, H. Bisphosphonates in osteoporosis: an initiation Osteoporosis Int. 3: S3–S5, 1993.

Fujita, T., Yoshikawa, S., Ono, OK., Inoue, T., & Orimo, H. Usefulness of TC-80 (ipriflavone) tablets in osteoporosis: A multicenter, double-blind, fake tablet-regulated examination Igaku Noayumi 138: 113–141, 1986.

Gallagher, J.C., Satpathy, R., Rafferty, ok., and Haynatzka, V. The effect of soy protein isolate on bone metabolism Menopause 11: 290–298, 2004

Greendale, G.A., FitzGerald, G., Huang, M.-H., Sternfeld, B., Gold, E., Seeman, T., Sherman, S., and Sowers, M.F. Nutritional soy isoflavones and cartilage now not organic mass: effects from a study of women's energy throughout the United States with its very own government Am J Epidemiol, 155: 746–754, 2002.

Garnero P., Markers of bone turnover for the prediction of fracture threat. Osteoporos Int eleven (Suppl 6): S55–65, 2000.

Genant, H.ok., Cooper, C., bad, G., Reid, I., Ehrlich, G., Kanis, J., Nordin, B.E.C., Barrett-Connor, E., Black, D., Bonjour, J.-P., Dawson-Hughes, B., Delmas, P.D., Dequeker, J., Ragi Eis, S., Gennari, C., Johnell, O., Johnston, C.C., Jr., Lau, E.M.C., Liberman, Lindsay, R., Martin, T.J., Martin, T.J., Martin, T.J., Masri, Mautalen, C.A., Meunier, P.J., Miller, P.D., Mithal, Morii, H., Papapoulos, S.,for Osteoporosis. Osteoporos Int 10: 259–264, 1999.

Groeneveld, F.P., Bareman, F.P., Barentsen, R., Dokter, H.J., Drogendijk, A.C., and Hoes, A.W. The duration of hormonal substitute analysis is commonly practiced as an effect lookahead. Maturitas 29: one hundred twenty-five–131, 1998 78. Schneider D.L., Barrett-Connor E.L., and Morton D.J., Timing of postmenopausal estrogen for max cartilage, now not natural mass Rancho Bernardo study, JAMA 277: 543-547, 1997.

Harkness, L.S., Fiedler, OK., Sehgal, A.R., Oravec, D., and Lerner, E. reduced bone resorption with soy isoflavone supplementation in postmenopausal ladies. J ladies' fitness 13: a thousand–1007, 2004.

Heaney, R.P., The Bone-remodeling short: Implications for the interpretation of scientific studies on Bone Mass exchange J Bone Miner Res nine: 1515–1523, 1994.

Heaney, R.P., Recker, R.R., and Stegman, M.R., will also be A.J. Calcium absorption in ladies: relationships to calcium consumption, estrogen popularity, and age. J Bone Miner Res: 469–475, 1989.

Ho, S.C., Chan, S.G., Yi, Q., Wong, E., Leung, %. Soy intake and the protection of height bone mass in Hong Kong Chinese women. J Bone Miner Res sixteen: 1363–1369, 2001.

Ho, S. C., Wong, E., Chan, S. G., Lau, J., Chan, C., and Leung, P. C. The purpose of height cartilage bulk in Chinese other halves has been antique 21–40 age. III. Bodily activity and cartilage now have organic bulk. J Bone Miner Res 12: 1262–1271, 1997.

Ho, S.C., Bacon, E., Harris, T., Looker, A., and Muggi, S. Hip rupture fees in Hong Kong and the United States, 1988–1989, Am J Public Fitness eighty-three: 694–697, 1993.

Hsu, C.-S., Shen, W.W., Hsueh, Y.-M., and Yeh, S.-L. Soy isoflavone supplementation in postmenopausal women: outcomes on plasma lipids, antioxidant enzyme sports, and bone density. J Reprod Med 46forty-six: 221–226, 2001.

Heaney, R.P. Calcium, creamery devices, and osteoporosis J Am Coll Nutr 19: 83S–99S, 2000. Nieves, J.W., Komar, L., Cosman, F., and Lindsay, R. Calcium potentiates the effect of estrogen and calcitonin on cartilage bulk: evaluation and reasoning Am J Clin Nutr 67: 18–24, 1998.

Kessel, B. Alternatives to estrogen in menopausal better halves, Proc Soc Exp Biol Med 217(1): 38–44, 1998.

Kerstetter, J.E., O'Brien, OK., and Insogna, OK., dietary protein, and intestinal calcium absorption, Am J Clin Nutr 73: 990–992, 2001.

Kimira, M., Arai, Y., Shimoi, K., and Watanabe, S., eastern consumption of flavonoids and isoflavonoids from delicacies J Epidemiol 8: 168–175, 1998.

Kurzer M.S., Xu X., Nutritional phytoestrogens. Annu Rev Nutr 17: 353–381, 1997.

Kuiper, G.G., Lemmen, J.G., Carlsson, B., Corton, J.C., Secure, S.H., Camper der Saag, P.T., Camper der Burg, B., and Gustafsson, J.A., the interaction of estrogenic chemical compounds and phytoestrogens accompanying estrogen receptors Endocrinology 139: 4252–4263, 1998.

Kardinaal, A.F.M., Morton, M.S., Bruggemann-Rotgans, I.E.M., and Camper Beresteijn, E.C.H., Phytoestrogen expulsion and rate of cartilage deficit in postmenopausal daughters, Eur J Clin Nutr 52: 850–855, 1998. Thompson, L. U., Robb, P., Serrano, M., and Cheung, F. Mammalian lignans result from differing meals. Nutr Cancer 16:43–52, 1991, Zhang, X., Shu, X.-O., Li, H., Yang, G., Li, Q., Gao, Y.-T., and Zheng, W. Potential follower examines soy bread devouring and risk of cartilage rupture between postmenopausal daughters Arch Intern Med a hundred sixty-five: 1890–1895, 2005

Komulainen, M., Kroger, H., Tuppurainen, M.T., Heikkinen, A.M., Alhava, E., Honkanen, R., Jurvelin, J., Saarikoski, S. Prevention of femoral and lumbar cartilage misfortune accompanying birth control method substitute remedy and supply of nourishment D3 in early postmenopausal other halves: A community-placed 5-period randomized trial 1999, J Clin Endocrinol Metab eighty-four: 546–552.

Kanis, J.A., Melton, L.J., III, Christiansen, C., Johnston, C.C., and Khaltaev, N.: Prognosis of osteoporosis. J Bone Miner Res 9: 1137–1141, 1994.

Karpf, D.B.; Shapiro, D.R.; Seeman, E.; Ensrud, K.E.; Johnston, C.C.; Adami, S.; Harris, S.T.; Santora, A.C.; Hirsch, L.J.; Oppenheimer, L.; Thompson, D. Prevention of nonvertebral fractures by way of alendronate: a meta-study JAMA 277(14): 1159–1164, 1997. Overgaard, OK., Hansen, M. A., Jensen, S. B., and Christiansen, C. Impact of following a timed nasal presidency of calcitonin on cartilage bulk and rupture costs in settled osteoporosis: A prescription-solution look at Br Med J 305: 556–561, 1992.

Kung, A.W.C., Luk, adequate. D.k., Chu, L.W., and Chiu, P.k.Y. Age-related osteoporosis in Chinese language: an evaluation of the reaction of intestinal calcium absorption and calcitropic hormones to dietary calcium deprivation Am J Clin Nutr 68: 1291–1297, 1998.

Kreijkamp-Kaspers, S., Kok, L., Grobbee, D.E., de Haan, E.H.F., Aleman, A., Lampe, J.W., and van der Schouten, Y.T., the effect of soy protein containing isoflavones on cognitive characteristics, bone mineral density, and plasma lipids in postmenopausal ladies JAMA 292: 65,74 2004.

Lydeking-Olsen, E.; Beck-Jensen, J.-E.; Setchell, k. D.R., Holm-Jensen, T. Soy milk or progesterone for preventing bone loss: a 2 12 months randomized, placebo-controlled trial. Eur J Nutr 40-three: 246–257, 2004

Lips, P., Duong, T., Oleksik, A., Black, D., Cummings, S., Cox, D., and Nickelsen, T. A all-encompassing examine of supply of nourishment D rank and parathyroid feature in postmenopausal moms accompanying osteoporosis: a well-known file from the assorted consequences of raloxifene judgment in a dispassionate trial J Clin Endocrinol Metab 86: 1212–1221, 2001. Kantorovich, V., Gacad, M.A., Seeger, L.L., and Adams, J.S. Bone, no longer organic bulk, increases accompanying supply of nourishment D satiation in inmates with accompanying supply of nourishment D lack and fundamental hyperparathyroidism. J Clin Endocrinol Metab 85: 3541–3543, 2000. Adams, J.S., Kantorovich, V., Wu, C., Javanbakht, M., and Hollis, B.W. Decision of the supply of nourishment D lack in osteopenic victims consequences in the speedy development of cartilage, no longer organic mass. J Clin Endocrinol Metab 84: 2729–2730, 1999. 97 Bryant, H. U.; Dere, W. H. Selective estrogen receptor modulators: an alternative to delivery control techniques and an alternative therapy Proc Soc Exp Biol Med 217(1): 45–52, 1998 Havsteen B. Flavonoids, a class of regular compounds accompanying severe pharmacological effectiveness Biochem Pharmacol 32: 1141–1148, 1983. 99. Agnusdei, D., Zacchei, F., Bigazzi, S., Cepollaro, C., Nardi, P., Montagnani, M., Gennari, C. Metabolic and dispassionate outcomes of ipriflavone in postmenopausal osteoporosis drugs Exp Clin Res 15: 97–104, 1989. 100Yamazaki I, Shino A, Shimizu Y., Tsukuda R., Shirakawa Y., and Kinoshita M. Impact of ipriflavone on glucocorticoid-inferred osteoporosis in rats Sci. 38: 951–958, 1986. Yamazaki, I., Shino, A., and Tsukuda, R. Effect of ipriflavone on ovariectomy-caused osteoporosis in rats J Bone Min Metab 3: 205-210, 1986. Dei D., Gennari C., and Bufalino L. Prevention of early postmenopausal bone loss using low doses of conjugated estrogens and the non-hormonal, bone-active drug ipriflavone Osteoporos Int five(6): 462-466, 1995. Alexandersen, P., Toussaint, A., Christiansen, C., Devogelaer, J.-P., Roux, C., Fechtenbaum, J., Gennari, C., and Reginster, J.Y., for the Ipriflavone Multicenter European Fracture, examine Ipriflavone inside the remedy of postmenopausal osteoporosis. JAMA 285: 1482–1488,

Looker, A.C., Orwoll, E.S., Johnston, C.C., Jr., Lindsay, R.L., Wahner, H.W., Dunn, W.L., Calvo, M.S., Harris, T.B., and Heyse, S.P., the incidence of reduced femoral cartilage mass in earlier American folks from NHANES III. J Bone Miner Res 12: 1761–1768, 1997.

Lau, E. M. C., Suriwongpaisal, P., Lee, J. K., Das De, S., Festin, M. R., noticed, S. M., Khir, A., Torralba, T., Sham, A., and Sambrook, P. Risk determinants for elegant spoilage in Asian people of community: The Asian Osteoporosis Study, J Bone Miner Res 16: 572–580, 2001.

Lau, E.M.C., Osteoporosis in Asians: The characteristic of Calcium and exceptional nutrients Mod Med 7: 45–50, 1994.

Liberman, S. Are the dissimilarities betwixt estradiol and introduced estrogens always happening or artificial, truly bearing on syntax? J Clin Endocrinol Metab 81:850, 1996.

Markiewicz, L.; Garey, J.; Adlercreutz, H.; Gurpide, E. In vitro biochemical assays of nonsteroidal phytoestrogens. J Steroid Biochem Mol Biol 45: 399–405, 1993.

Maskarinec, G., Singh, S., Meng, L., and Franke, A. A., dietary soy consumption and urinary isoflavone expulsion between daughters in a multiethnic human being: most cancers Epidemiol Biomark Prev 7: 613–619, 1998.

Manolagas, S. C., and Jilka, R. L. Mechanisms of agony: cartilage essence, cytokines, and cartilage protection: rising visions into the pathophysiology of osteoporosis 1995, N Engl J Med 332:305–311. 71. Scharbo-DeHaan, M. Hormone replacement analysis Nurs: Pract. 21 (12 Pt. 2): 1–13, 1996. Beresford S.A.A., Weiss N.S., McKnight B. Hazard of endometrial malignancy having to do with the usage of estrogen-linked accompanying recurrent progestagen medicine in postmenopausal women. Lancet 349: 458–461, 1997.

McNagny, S.E., Prescription of Start Manipulating Techniques as Alternative Cures for Menopausal Syndromes Ann Intern Med 131: 605–616, 1999. Eastell, R. Postmenopausal osteoporosis state of affairs, N Engl J Med 338: 736-746, 1998.

Messina, M., Gugger, E. T., and Alekel, D. L. Soy protein, soybean isoflavones, and cartilage health: an evaluation of animal and human files Soy protein, soybean isoflavones, and cartilage power: an evaluation of the animal and human file within the guide to Nutraceuticals and purposeful ingredients, R.E.C. Wildman (Ed.), CRC Press, Boca Raton, FL, 2001, pp. 77–98,

Melton, L.J., III; Chrischilles, E.A.; Cooper, C.; Lane, A.W.; Riggs, B.L. attitude: how many wives do you have with osteoporosis? J Bone Miner Res 7: 1005–1010, 1992.

Melton, L. J., III; Therneau, T. M.; Larson, D. R., Long-time period flows in elegant ruin predominance: the influence of contemporary rupture occurrence and endurance. Osteoporos Int. 8: 68–74, 1998.

Melton, L.J., III; Riggs, B.L., Epidemiology of Person-Related Fractures: Osteoporotic Syndrome, Ed. Avioli, A.V., New York, Grune and Stratton, 1983, pp. 45–72.

Melton, L.J., III. Who has osteoporosis? The conflict between dispassionate and community fitness outlooks J Bone Miner Res. 15: 2309–2314, 2000.

Melton, L.J., III., On what number of other halves do you have osteoporosis? J Bone Miner Res., 10: a hundred seventy-five–177, 1995.

Morgan, S.L., Calcium, and source of nutrition D tiers in osteoporosis Rheum Dis Clin N Am 27: 101–130, 2001. meals and Nutrition Board, Institute of Drugs: Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, vitamin D, and Fluoride Washington, D.C.: Countrywide Academy Press, 1997.

Nine. Anthony, M.S., Anderson, J.J.B., and Alekel, D.L., Affiliation between soy and/or isoflavones and cartilage: proof from epidemiological studies. Phytoestrogens and fitness, Eds., Gilani, G.S., and Anderson, J.J.B., American Oil Chemists' Society Press, Champaign, IL, 2002, pp. 331–340.

Nakamura, T., Turner, C.H., Yoshikawa, T., Slemenda, C.W., Peacock, M., Burr, D.B., Mizuno, Y., Orimo, H., Ouchi, Y., and Johnston, C.C., Jr. Do alternatives in current mathematics analyze the dissimilarities in modern damage hazards between Japanese and White Americans? J Bone Miner Res 9: 1071–1076, 1994.

Parker, M., Anand, J. okay., Myles, J. W., and Lodwick, R. Proximal femoral fractures: predominance of detached ethnic agencies Eur J Epidemiol 8: 730–732, 1992.

Prentice, A.; Parsons, T.J.; Cole, T.J. The unfussy use of cartilage no longer organic bulk in absorptiometry concedes the opportunity to bring about period-accompanying artifacts within the labeling of cartilage no longer organic cause. Am J Clin Nutr 60: 837–842, 1994.

Potter, S.M., Baum, J.A., Teng, H., Stillman, R.J., Shay, N.F., and Erdman, J.W., Jr., consequences of soy protein and isoflavones on ancestry lipids and cartilage bulk in postmenopausal girls, Am J Clin Nutr 68: 1375S–1379S, 1998.

Pun, k.good enough., Chan, L.W.L., Chung, V., and Wong, F.H.W. Calcium and specific nutritional components in Hong Kong Chinese language concerning age and osteoporosis J Appl Nutr 40-3: 12–17, 1990.

Pines, A., Katchman, H., Villa, Y., Mijatovic, V., Dotan, I., Levo, Y., Ayalon, D. The impact of numerous hormonal arrangements and calcium supplementation on bone mass in early menopause. Is there a predictive cost for the preliminary bone density and frame weight? J Intern Med 246: 357–61 1999

Ross, P.D., Norimatsu, H., Davis, J.W., Yano, K., Wasnich, R.D., Fujiwara, S., Hosoda, Y., and Melton, J., III. assessment of smart rupture occurrence between native eastern, Japanese American, and American Caucasian societies, Am J Epidemiol 133: 801–809, 1991.

Rogmark, C., Sernbo, I., Johnell, O., and Nilsson, J.-., the incidence of recent fractures Malmö, Sweden, 1992–1995. Acta Orthopaed Scand 70: 19–22, 1999.

Ross, P.D., He, Y.-F., Yates, A.J., Coupland, C., Ravn, P., McClung, M., Thompson, D., and Wasnich, R.D. The frame amount accounts for most of the differences in cartilage mass between Asian and Caucasian ladies. Calcif Tissue Int 59: 339–343, 1996.

Ross, P.D., Fujiwara, S., Huang, C., Davis, J.W., Epstein, R.S., Wasnich, R.D., Kodama, okay., and Melton, J., III. Vertebral rupture predominance in moms in Hiroshima outstanding to Caucasians or Japanese daughters inside the U.S. Int J Epidemiol 24: 1171–1177, 1995.

Roughead, Z. good enough., Hunt, J.R., Johnson, L. good enough., Badger, T.M., and Lykken, G.I., controlled substitution of soy protein for meat protein: outcomes on calcium retention, bone, and cardiovascular health indices in postmenopausal ladies. J Clin Endocrinol Metab 90: 181–189, 2005.

Ross, P.D., Predicting bone loss and fracture dangers with biochemical markers: an overview J Clin Density Geometry 2: 285–294, 1999.

Scheiber, M.D.; Rebar, R.W. Isoflavones and postmenopausal cartilage well-being: a possible alternative to estrogen treatment? Menopause 6: 233–241, 1999.

Setchell, OK.D., and Cassidy, A., dietary isoflavones: organic assets and pertinence to human well-being, J Nutr 129: 758S–767S, 1999.

Somekawa, Y., Chiguchi, M., Ishibashi, T., and Aso, T. Soy intake had references to menopausal manifestations, antitoxin lipids, and cartilage, not natural bulk, in postmenopausal Japanese mothers. Obstet Gynecol Ninety-Seven: 109–a hundred and fifteen, 2001.

Setchell, ok. D.R. Non-steroidal estrogen of abstinence from food inception: workable responsibility in well-being and agony, absorption, and corporal property, Proc Nutr Soc NZ 20: 1–21, 1995.

Shutt, D. A.; Cox, R. I. Steroid and phytoestrogen binding to the chief uterine receptors is artificial. Steroid and phytoestrogen binding in a mass of water debris in air uterine receptors is artificial. Endo Chronicle fifty-two: 299–310, 1972

Sebastian, A. Low versus excessive meat diets: effects on calcium metabolism J Nutr 133: 3237-3238, 2003.

Souberbielle, J.C., Cormier, C., and Kindermans, C. Bone markers in clinical exercise Curr Opin Rheu metal 11: 312–319, 1999.

Silverman, S.L., and Madison, R.E., decreased incidence of present-day fractures in Hispanics, Asians, and Blacks: California Clinic Discharge Dossier, Am J Public Health 78: 1482–1483, 1988.

Tsai, okay.S. Osteoporotic wreck price, cartilage no longer having natural bulk, and cartilage absorption in Taiwan, J Formos Med Assoc., ninety-six: 802–805, 1997.

Tune, T.T., Hendrich, S., and Murphy, P.A. Estrogenic motion of glycitein, a soy isoflavone J Agric Meals Chem 47: 1607–1610, 1999.Tucci, J.R., Osteoporosis Renovation Med Fitness R I 81: 169–73, 1998.

Tsai, okay., Twu, S., Chieng, P., Yang, R., and Lee, T., the incidence of vertebral fractures in Chinese people in Taiwanese towns Calcif Tissue Int 59: 249–253, 1996.

Tsai, okay., Huang, K., Chieng, P., and Su, C. Bone is not the natural bulk of ordinary Chinese daughters in Taiwan. Calcif Tissue Int 48: 161–166, 1991.

Tsuchida is okay; Mizushima is okay; Toba is okay; and Soda is okay. nutritional soybean intake and cartilage, not organic mass, among 995 middle-vintage daughters in Yokohama. J Epidemiol 9: 14–19, 1999.

Thamsborg G.: effect of a nasal mixture of pink and yellow calcitonin on calcium and cartilage absorption Dan Med Bull 46: 118–126, 1999. Silverman, S.L.: Calcitonin Rheum Dis Clin N Am 27: 187–196, 2001. Ilich, J.Z.; Kerstetter, J.E. Nutrients in cartilage strength are known as A and similarly calcium. J Am Coll Nutr 19: 715-737, 2000. North American Menopause Society. The act of calcium in fairy- and postmenopausal girls: the unity belief of the North American Menopause Society Menopause 8: 84–95, 2001.

U.S. Preventive offerings assignment pressure Postmenopausal delivery manipulation techniques substitute therapy for the fundamental forestall of incessant environments: suggestions and movement. Ann Intern Med 137: 834–839, 2002.

Watkins, T.R., Pandya, okay., and Mickelsen, O. Urinary acid and calcium excretion: impact of soy versus meat in human diets In nutritional Bioavailability of Calcium, Ed. Kies, C. American Chemical Society, Washington, D.C., 1985

Vidal, O., Kindblom, L. G., and Ohlsson, C. Expression and localization of estrogen receptors in rodent and human cartilages J Bone Mineral Res 14: 923–929, 1999.

Watts, N.B. Treatment of osteoporosis accompanying bisphosphonates Rheum Dis Clin N Am 27: 197–214, 2001. Adachi, J.D., Bensen, W.G., Brown, J., Hanley, D., Hodsman, A., Josse, R., Kendler, D.L., Lentle, B., Olszynski, W., St. Marie, L.-G., Tenenhouse, A., & Chines, A.A. Interdenominational evaluation for fear of corticosteroid-inferred osteoporosis N Engl J Med 337: 382–387, 1997. Liberman, U.A., Weiss, S.R., Broll, J., Minne, H.W., Quan, H., Bell, N.H., Rodriguez-Portales, J., Downs, R.W., Jr., Dequeker, J., Favus, M. Effect of spoken alendronate on cartilage, no longer organic bulk, and the prevalence of fractures in postmenopausal osteoporosis Alendronate segment III Osteoporosis treatment look at organization N Engl J Med 333(22): 1437–1443, 1995.

Weaver, C.M. Calcium necessities: the need to understand racial versions Editorial. Am J Clin Nutr 68: 1153–1154, 1998.

Writing group for ladies' fitness Initiative Investigators dangers and blessings of estrogen and progesterone in healthy postmenopausal girls JAMA 288: 321-333, 2002.

Wright, C.D.P., Garrahan, N.J., Stanton, M., Gazet, J.-C., Mansell, R.E., and Compston, J.E. impact of lengthy-term tamoxifen therapy on cancellous bone reworking and shape in women with breast cancer J Bone Miner Res nine: 153–159, 1994. a hundred and five. Love, R.R., Mazess, R.B., Barden, H.S., Epstein, S., Newcomb, P.A., Jordan, V.C., Carbone, P.P., and De Mets, D.L. outcomes of tamoxifen on bone mineral density in postmenopausal ladies with breast cancer N Engl J Med 326: 852–856, 1992. 106. Fornander, T., Rutquist, L.E., Cedermark, B., Glas, U., Mattsson, A., Silfversward, C., Skoog, L., Somell, A., Theve, T., Wilking, N., Askergren, J., Hjalmar, M.-L. Adjuvant tamoxifen for early breast cancer: incidence of recent primary cancers Lancet 1: 117–120, 1989. Delmas, P.D., Bjarnason, N.H., Mitlak, B.H., Ravoux, A.-C., Shah, A.S., Huster, W.J., Draper, M., Christiansen, C. results of raloxifene on bone mineral density, serum ldl cholesterol concentration, and uterine endometrium in postmenopausal girls N Engl J Med 337: 1641–1647, 1997. Heaney, R. P.; Draper, M. W. Raloxifene and estrogen: comparative bone remodeling kinetics J Clin Endocrinol Metab 82: 3425–3429, 1997. Walsh, B.W., Kuller, L.H., Wild, R.A., Paul, S., Farmer, M., Lawrence, J.B., Shah, A.S., and Anderson, P.W. results of raloxifene on serum lipid and coagulation aspect tiers in healthy postmenopausal girls JAMA 279(18): 1445–1451, 1998. 110. Gordon, S., Walsh, B.W., Ciaccia, A.V., Siddhanti, S., Rosen, A.S., and Pouffe, L. Transition from estrogen-progestin to raloxifene in postmenopausal girls: impact on vasomotor signs and symptoms Obstet Gynecol 103: 267–273, 2004. St. Germain, A., Peterson, C.T., Robinson, J., and Alekel, D.L. Isoflavone-rich or isoflavone-poor soy protein did no longer reduce menopausal signs during the 24 weeks of treatment. Menopause, 8(1): 17–26, 2001 Arjmandi, B.H., Alekel, L., Hollis, B.W., Amin, D., Stacewicz-Sapuntzakis, M., Guo, P., and Kukreja, S.C. nutritional soybean protein prevents bone loss in an ovariectomized rat version of osteoporosis. J Nutr 126: 161–167, 1996. Arjmandi, B.H., Salih, M.A., Herbert, D.C., Sims, S.H., Kalu, D.N. evidence of estrogen receptor-connected calcium delivery within the gut Bone Miner 21: 63–74; 1993. Spence, L.A., Lipscomb, E.R., Cadogan, J., Martin, B., Wastney, M.E., Peacock, M., and Weaver, C.M. impact of soy isoflavones on calcium metabolism in postmenopausal women: A randomized crossover look at Am J Clin Nutr 81: 916–922, 2005. Pennington, J.A.T. Bowes, and the Church's food Values of quantities commonly Used, 17th ed. Harper and Row (1998) Anderson, J., Thomsen, k., and Christiansen, C. High-protein meals, insular hormones, and urinary calcium excretion in human topics In lawsuits of the worldwide Symposium on Osteoporosis, Eds., C.

Xu, L., Lu, A., Zhao, X., Chen, X., and Cummings, S. R. Very reduced prices of new smash have taken place in Beijing, according to humans as political entities in the Republic of China and the Beijing Osteoporosis Task. Am J Epidemiol one hundred forty-four: 901–907, 1996.