Analysis of the Utilization of Rice Bran on Changes in Total Blood Cholesterol Concentration; An Update Systematic Review

St. Nur Azizah; Abdul Razak Thaha; Abdul Salam; Healthy Hidayanty; Citrakesumasari; Fridawaty Rivai

doi:10.55927/mudima.v3i1.2497

Authors

St. Nur Azizah Departemen Ilmu Gizi, Fakultas Kesehatan Masyarakat, UNHAS
Abdul Razak Thaha Departemen Ilmu Gizi, Fakultas Kesehatan Masyarakat, UNHAS
Abdul Salam Departemen Ilmu Gizi, Fakultas Kesehatan Masyarakat, UNHAS
Healthy Hidayanty Departemen Ilmu Gizi, Fakultas Kesehatan Masyarakat, UNHAS
Citrakesumasari Departemen Ilmu Gizi, Fakultas Kesehatan Masyarakat, UNHAS
Fridawaty Rivai Departemen Manajemen Rumah Sakit, Fakultas Kesehatan Masyarakat, UNHAS

DOI:

https://doi.org/10.55927/mudima.v3i1.2497

Keywords:

Rice Bran Oil, Total Cholesterol Changes, Dose

Abstract

The prevalence of coronary heart disease in Indonesia increased from 0.5% in 2013 to 1.5% in 2018. The risk factor is most commonly found to be an increase in cholesterol. The increase in cholesterol can be overcome by utilizing processed bran oil (RBO) as a supplement. The purpose of this systematic review is to examine the effectiveness of bran oil against changes in total blood cholesterol concentration based on dosage.This systematic review method is carried out based on the PRISMA flow diagram. The literature eligibility criteria are determined based on the PICOS framework. Literature searches and searches are conducted on the Crossref, DOAJ, Google Scholar, ProQuest, PubMed, and Science Direct databases. The screening stage is carried out with the help of the Mendeley application. Data extraction results are analyzed by searching for equations, comparisons and synthesizing data. The results of five selected articles and all of them show that consuming RBO has an effect on changes in total blood cholesterol concentrations. There are four articles using the RCT design and one article using the experimental design. The preparations and doses identified were RBO preparations at a dose of 45 ml/day and gamma-oryzanol-rich RBO at a dose of 15 ml/day (20.000 ppm gamma-oryzanol). RBO consumption is effective against changes in total blood cholesterol concentration with the use of different doses. We recommend that the next systematic review can examine the effects of various doses of bran oil using meta-analysis

References

Ali, A., Rice, S. D.-B., & 2017, undefined. (2017). Nutritional and health benefits of rice bran oil.Springer.https://link.springer.com/chapter/10.1007/978-3-319-59011-0_9

Arora, S., Sharma, S., Goel, S., & US, S. (2005). Use of Rice Bran Oil in Patients with Hyperlipidemia. Natl Med J India, 292–296.

Astawan, M., & Leomitro, A. (2009). Khasiat Whole Grain: Makanan Kaya Serat untuk Hidup Sehat. Gramedia Pustaka Utama.

Badan Kefarmasian dan Alat Kesehatan. (2017). Farmakope Herbal Indonesia. In Kemenkes RI (II). https://doi.org/10.1201/b12934-13

Berger, A., Rein, D., Schäfer, A., Monnard, I., Gremaud, G., Lambelet, P., & Bertoli, C. (2005). Similar cholesterol-lowering properties of rice bran oil, with varied γ-oryzanol, in mildly hypercholesterolemic men. European Journal of Nutrition, 44(3), 163–173. https://doi.org/10.1007/S00394-004-0508-9

Bumrungpert, A., Chongsuwat, R., Phosat, C., & Butacnum, A. (2018). Rice Bran Oil Containing Gamma-Oryzanol Improves Lipid Profiles and Antioxidant Status in Hyperlipidemic Subjects: A Randomized Double-Blind Controlled Trial. The Journal of Alternative and Complementary Medicine, 25(3), 353–358. https://doi.org/10.1089/acm.2018.0212

Citrakesumasari, Daud, N. A., Syam, A., Russeng, S., Hidayanty, H., Hadju, V., Burhanuddin, Baharuddin, Virani, D., Sipato, S. R., Auliya, H

Nuntung, M., & Amir, S. (2021). Effects of Rice Bran Oil on Lipid Profiles of Hypercholesterolemic Junior High School Teachers. Current Research in Nutrition and Food Science Journal, 9(3), 1090–1103. https://doi.org/10.12944/CRNFSJ.9.3.34

Devarajan, S., Chatterjee, B., Urata, H., Zhang, B., Ali, A., Singh, R., & Ganapathy, S. (2016). A Blend of Sesame and Rice Bran Oils Lowers Hyperglycemia and Improves the Lipids. The American Journal of Medicine, 129(7), 731–739. https://doi.org/10.1016/J.AMJMED.2016.02.044

Eady, S., Wallace, A., Willis, J., Scott, R., & Frampton, C. (2011). Consumption of a Plant Sterol-Based Spread Derived from Rice Bran Oil is Effective at Reducing Plasma Lipid Levels in Mildly Hypercholesterolaemic Individuals. British Journal of Nutrition, 105(12), 1808–1818. https://doi.org/10.1017/S0007114510005519

Erlinawati, N. D., Oetoro, S., & Gunarti, D. R. (2017). Effect of Rice Bran Oil on the Lipid Profile of Mild-Moderate Hypercholesterolemic Male Aged 19-55 year. World Nutrition Journal, 1(1),51–56. https://doi.org/10.25220/WNJ.V01I1.0010

Garnadi Y. (2012). Hidup Nyaman Dengan Hiperkolesterol. Argo Media Pustaka.

Hadipernata, M. (2007). Mengolah Dedak Menjadi Minyak (Rice Bran Oil). In Warta Penelitian dan Pengembangan Pertanian (Vol. 29, Issue 4).

Hanmoungjai, P., Pyle, D. L., & Niranjan, K. (2001). Enzymatic process for extracting oil and protein from rice bran. Journal of the American Oil Chemists’ Society, 78(8), 817–821. https://doi.org/10.1007/s11746-001-0348-2

Hanum, G. R., & Ardiansyah, S. (2018). Deteksi Dini Penyakit Degeneratif pada Remaja Anggota Karang Taruna. Jurnal Abadimas Adi Buana, 2(1), 1–3. https://doi.org/10.36456/abadimas.v2.i1.a1615

Henderson, A. J., Ollila, C. A., Kumar, A., Borresen, E. C., Raina, K., Agarwal, R., & Ryan, E. P. (2012). Chemopreventive Properties of Dietary Rice Bran: Current Status and Future Prospects. Advances in Nutrition, 3(5), 643–653. https://doi.org/10.3945/an.112.002303

Imam, S. (2004). Serangan Jantung dan Stroke Hubungannya dengan Lemak dan Kolesterol. Gramedia Pustaka Utama.

Jolfaie, N. R., Rouhani, M. H., Surkan, P. J., Siassi, F., & Azadbakht, L. (2016). Rice Bran Oil Decreases Total and LDL Cholesterol in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Hormone and Metabolic Research, 48(7), 417–426.

Kemenkes RI. (2017). Formularium Ramuan Obat Tradisional Indonesia. In Keputusan Menteri Kesehatan Republik Indonesia. https://pesquisa.bvsalud.org/portal/resource/en/mdl-20203177951%0Ahttp://dx.doi.org/10.1038/s41562-020-0887-9%0Ahttp://dx.doi.org/10.1038/s41562-020-0884-z%0Ahttps://doi.org/10.1080/13669877.2020.1758193%0Ahttp://sersc.org/journals/index.php/IJAST/article

Kharisma, T. (2015). Studi Hipokolesterolemik Beras Analog Secara In Vivo Pada Tikus Sprague dawley (SD).

Kota, S., Kota, S., Krishna, S. S., Meher, L., Modi, K., Rao, E., & Jammula, S. (2013). Nutraceuticals in Dyslipidemia Management. Journal of Medical Nutrition and Nutraceuticals, 2(1), 26. https://doi.org/10.4103/2278-019X.105328

Kuriyan, R., Gopinath, N., Vaz, M., & Kuroad, A. V. (2005). Use of Rice Bran Oil in Patients with Hyperlipidemia. Natl Med J India, 18(6).

Lai, M.-H., Chen, Y.-T., Chen, Y.-Y., Chang, J.-H., & Cheng, H.-H. (2012). Effects of Rice Bran Oil on The Blood Lipids Profiles and Insulin Resistance in Type 2 Diabetes Patients. Journal of Clinical Biochemistry and Nutrition, 51(1), 15–18. https://doi.org/10.3164/JCBN.11-87

Libby, P., Buring, J. E., Badimon, L., Hansson, G. K., Deanfield, J., Bittencourt, M. S., Tokgözoğlu, L., & Lewis, E. F. (2019). Atherosclerosis. Nature Reviews Disease Primers, 5(1), 56. https://doi.org/10.1038/s41572-019-0106-z

Nasir, S., Fitriyanti, & Kamila, H. (2009). Ekstraksi Dedak Padi Menjadi Minyak Mentah Dedak Padi (Crude Rice Bran Oil) dengan Pelarut N-Hexane dan Etanol. Jurnal Teknik Kimia, 16(2).

Ojah, K., Gogoi, G., Chaliha, M., & Borah, A. (2017). Hypolipidemic Effect of RICE Bran Oil and Olve Oil Hypercholesterolemic Rats. Indian J Basic Appl Med Res, 98–108.

Rajnarayana, K., Prabhakar, M., & Krishna, D. (2001). Influence of Rice Bran Oil on Serum Lipid Peroxides and Lipid in Human Subjects. Indian J Physiol Pharmacol, 442–444.

Riskesdas. (2018). HASIL UTAMA RISKESDAS 2018.

Rukmini, C., & Raghuram, T. C. (1991). Nutritional and biochemical aspects of the hypolipidemic action of rice bran oil: a review. Journal of the American College of Nutrition, 10(6), 593–601. https://doi.org/10.1080/07315724.1991.10718181

Vorarat, S. M., Iamthanakul, L., Soparat, W., & Kamkaen, N. (2010). Examination of Antioxidant Activity and Development of Rice Bran Oil and Gamma-Oryzanol Microemulsion. J Health Rest, 24(2), 67–72.

Wang, O., Liu, J., Cheng, Q., Guo, X., Wang, Y., Zhao, L., Zhou, F., & Ji, B. (2015). Effects of Ferulic Acid and γ-Oryzanol on High-Fat and High-Fructose Diet-Induced Metabolic Syndrome in Rats. PLOS ONE, 10(2), e0118135. https://doi.org/10.1371/journal.pone.0118135

Wijayanthie, N., Gunarti, D. R., Manikam, N. R., & Yulhasri. (2019). Effects of Extra Virgin Olive Oil Versus Rice Bran Oil on Glycemic Control in Patients with Type-2 Diabetes Mellitus. International Journal of Applied Pharmaceutics, 56–59. https://doi.org/10.22159/ijap.2019.v11s6.33540

World Health Organization. (2018). Noncommunicable Disease Country Profiles 2018. In Heart of Africa: Clinical Profile of an Evolving Burden of Heart Disease in Africa. https://doi.org/10.1002/9781119097136.part5

World Health Statistic. (2017). STATUS OF THE HEALTH-RELATED SDGs

Zavoshy, R., Noroozi, M., & Jahanihashemi, H. (2012). Effect of Low Calorie Diet with Rice Bran Oil on Cardiovascular Risk Factors in Hyperlipidemic Patients. Journal of Research in Medical Sciences, 626–631. https://doaj.org/article/684a3f0cfcb9472ab066d2938bacce84