Relationship Between Age and Depth of Invasion and Histopathological Features in Colorectal Cancer Patients in the Anatomical Pathology Department of Cut Meutia General Hospital (RSUCM) 2018 - 2021

Mulyati Sri Rahayu; Khairunnisa Z; Nabil Ibnu Sina

doi:10.55927/mudima.v3i4.2929

Authors

Mulyati Sri Rahayu Universitas Malikussaleh, Lhokseumawe
Khairunnisa Z Universitas Malikussaleh, Lhokseumawe
Nabil Ibnu Sina Universitas Malikussaleh, Lhokseumawe

DOI:

https://doi.org/10.55927/mudima.v3i4.2929

Keywords:

Colorectal Cancer, Age, Depth of Invasion, Histopathological Features

Abstract

Colorectal cancer has become one of the most common and most diagnosed cancers in the world, with as many as 1.4 million new cases being discovered each year. This cancer affects many elderly patients, but not a few young patients also experience it. Depth of invasion and type of histopathological appearance are the determining factors in determining the prognosis of colorectal cancer. The purpose of this study was to determine the relationship between age and depth of invasion and histopathological features in patients with colorectal carcinoma in the anatomical pathology section of RSU Cut Meutia, North Aceh for the 2018-2021 period. This research is a retrospective analytic study using the approach cross sectional study and use data taken from the results of laboratory examinations. Anatomical Pathology during the 2018-2021 period. The results of the study found that cancer that had invaded the subserosa to the peri-colorectal tissue (T3) and invaded other organs and/or perforated visceral peritoneum (T4) had a higher percentage in the age group.≤54 years, but statistically no significant relationship was found. Description adenocarcinoma is the most common histopathological appearance and has a higher percentage in the age group≤54 years, but statistically no significant relationship was found. So it can be concluded that there is no significant relationship between age and depth of invasion and the histopathological appearance of colorectal cancer patients

References

Abdullah, M.et al. (2012) ‘Molecular Profile of Colorectal Cancer in Indonesia: Is There Another Pathway?’, Gastroenterology and Hepatology From Bed to Bench, 5(2), p. 71–78. doi: 10.22037/ghfbb. v5i2.245.

About Colorectal Cancer; What Is Colorectal Cancer ?’ (2021) American Cancer Society, pp. 1–15. Available at: https://www.cancer.org/cancer/colon-rectal-cancer/about.html.

Abubakar, A. (2012) ‘Colorectal Cancer Screening Programme: Strategies and Opportunities in Priority Populations’, Indonesian Digestive Disease Week., pp. 59–66.

Ahmad Yusra, C. (2012) 'Description of Colorectal Cancer Patients at dr. Soedarso Pontianak Period 2006 - 2010', Tanjungpura University Journal.

Arnold, M. et al. (2017) ‘Global Patterns and Trends in Colorectal Cancer Incidence and Mortality’, Gut, 66(4), pp. 683–691. doi: 10.1136/gutjnl-2015-310912.

Bong, J.et al. (2022) ‘Prognosis and Sensitivity of Adjuvant Chemotherapy in Mucinous Colorectal Adenocarcinoma without Distant Metastasis’, MDPI Cancers, pp. 1–14.

Brunicadi, F.et al. (2017) Schwartz’s principles of surgery. 8th edn. New York: The McGraw – Hill Companier.

Desen, W. and Japaries, W. (2013) Clinical oncology, Faculty of Medicine, University of Indonesia. 2nd edn. Jakarta: Publishing Center of the Indonesian Faculty of Medicine. Available at: https://lib.ui.ac.id/detail?id=20417330&location=lokal.

Farhan Hasan, M. (2022) 'Characteristics of the Clinicopathology of Colorectal Cancer in the Anatomical Pathology Laboratory of RSUP dr. M. Djamil, Padang in 2017-2020', Andalas University.

Feldman, M., Friedman, L. and Brandt, L. (2015) Gastrointestinal and Liver Disease. 10th edn.

Gunasekaran, V., Ekawati, N. P. and Sumadi, I. W. J. (2019) 'Clinicopathological characteristics of colorectal carcinoma in Sanglah General Hospital, Bali, Indonesia in 2013-2017',Digest of Medical Science, 10(3), pp. 552–556. doi: 10.15562/ism. v10i3.458.

Ministry of Health (2018) 'National Guidelines for Medical Services for the Management of Colorectal Cancer',National Guidelines. Available at:http://kanker.kemkes.go.id/guidelines/PNPKkolorektal.pdf.

Kurahmawati, A. (2012) 'Relationship between characteristics (age and sex) and serum triglyceride levels with the incidence of colorectal carcinoma in Dr. Kariadi Semarang',FK Undip, pp. 1–63.

Kurniawan, T., Zahari, A. and Asri, A. (2017) 'Age Relationship with Depth of Invasion and Histopathological Features in Patients with Colorectal Carcinoma in the Anatomical Pathology Department, UNAND Faculty of Medicine in 2008 to 2012',Andalas Health Journal6(2), p. 351. doi: 10.25077/jka. v6i2.703.

Lihawa, L. and Zainuddin, R. (2022) 'Anxiety Level of Cancer Patients Undergoing Chemotherapy During the Covid-19 Pandemic: Literature Review', Baiturrahim Jambi Academic Journal, 11(1), p. 96. doi: 10.36565/jab. v11i1.457.

Majid, S. R. and Ariyanti, F. (2020) 'Determinants of Colorectal Cancer Occurrence',Journal of Public Health Sciences, 9(04), pp. 208–215. doi: 10.33221/jikm. V9i04.677.

Mojarad, Ehsan N., Kuppen, Peter JK., Aghdaei, Hamid A., & Zali, M. R. (2013) The CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer, Springer Nature. Gewerbestrasse, Switzerland.

Pereira, A.A.L.et al. (2020) ‘Differences in Pathology and Mutation Status Among Colorectal Cancer Patients Younger Than, Older Than, and of Screening Age’, Clinical colorectal cancer and Other Gastrointestinal Malignancies. doi: https://doi.org/10.1016/j.clcc.2020.06.004.

Pratama, K. P. and Adrianto, A. A. (2019) 'Factors Influencing the Incidence of Stage III Colorectal Cancer at Dr. Kariadi General Hospital Semarang', Diponegoro Medical Journal (Diponegoro Medical Journal), 8(2), pp. 768–784.

Robbins, S. L., Ramzi S., C. and Kumar, V. (2018) Robbins Basic Pathology Vol. 1. 10th edn. Pennsylvania: Elsevier Saunders.

Sander, M. A. (2012) 'Colorectal Cancer Profile at Hasan Sadikin Hospital Bandung',Nursing Journal, (3) 1, pp. 9 – 21. doi: https://doi.org/10.22219/jk.v3i1.1048.

Subrata, F. H. (2020) Colorectal Cancer Survival at RSUPN Dr. Cipto Mangunkusumo. Jakarta: Study Program of Surgery.

Sudoyo, A.W.et al. (2010) ‘Colorectal cancer among young native indonesians: A clinicopathological and molecular assessment on microsatellite instability’, Medical Journal of Indonesia, 19(4), pp. 245–251. doi: 10.13181/city. v19i4.411.

Sutrisna, I.W.W., Sudartana, I.K., Widiana, I. G. R. (2018) ‘Correlation Between Histopathologic Grading and Carcinoembryonic Antigen Levels in Colon Carcinoma’, Medicine, pp. 49(1): 22–28.

WHO (2020) ‘International Agency for Research on Cancer, Globocan’. Available at: https://gco.iarc.fr/today/data/factsheets/cancers/10_8_9-Colorectum-fact-sheet.pdf.