The Relationship between the Ratio of Neutrophil and Lymphocyte in Preeclampsia Patients

Authors

  • Intan Nabilla Ayuni Universitas Syiah Kuala
  • Cut Meurah Yeni Universitas Syiah Kuala
  • Husnah Husnah Universitas Syiah Kuala
  • Sakdiah Sakdiah Universitas Syiah Kuala

DOI:

https://doi.org/10.55927/ajha.v4i1.14391

Keywords:

Neutrophils and Lymphocytes Ratio, Preeclampsia, Severe Preeclampsia

Abstract

Preeclampsia is a hypertensive disorder with elevated blood pressure and proteinuria after 20 weeks of gestation, often involving an exaggerated inflammatory response. This study examined the relationship between the neutrophil-to-lymphocyte ratio (RNL) and preeclampsia. A retrospective analytic study with a cross-sectional approach analyzed medical records of 106 inpatients at Zainoel Abidin Hospital Banda Aceh from January to December 2020. Most patients were aged 20-35 years (64.2%), college-educated (38.8%), housewives (68.9%), and multiparas (62%). RNL analysis showed 8.6% normal and 91.4% abnormal in severe preeclampsia cases. The Spearman correlation test showed p=0.367 (p>0.05), indicating no significant relationship between RNL and preeclampsia. The mean RNL was 6.5267 in preeclampsia and 8.3106 in severe cases, both exceeding the normal cut-off of 4.8. There was no relationship between RNL and preeclampsia, but the mean RNL values were above normal.

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References

Abd-Alazim, M., Mohammad, A. H., Radwan, M. S., & Shokr, A. A. (2018). Is Neutrophil/Lymphocyte Ratio A Useful Marker to Predict the Severity of Pre-Eclampsia?. The Egyptian Journal of Hospital Medicine, 73(5), 6621-6625.

Amanda, D. A. (2020). Rasio neutrofil-limfosit pada covid-19; sebuah tinjauan literatur. Wellness And Healthy Magazine, 2(2), 219-223.

Budi Juliantari K, Hariyasa Sanjaya I. (2017). Karakteristik Pasien Ibu Hamil Dengan Preeklampsia Di RSUP Sanglah Denpasar Tahun 2015. E- Jurnal Medical Udayana. 2017;6(4):1– 9.

Damayanti, S., Sulistyowati, S., & Probandari, A. N. (2019). Maternal characteristics and the effects of early and late-onset types of preeclampsia on maternal and perinatal complications. Indonesian Journal of Medicine, 4(4), 329-338.

Elsanti BD. (2020). Hubungan Antara Tingkat Stress dan Aktivitas Fisik Terhadap Kejadian Preeklampsian Pada Ibu Hamil di Wilayah Puskesmas Kalibagor.

Faiqoh E, Hendrati LY. (2018). Hubungan karakteristik ibu, ANC dan kepatuhan perawatan ibu hamil dengan terjadinya preeklampsia. Jurnal Kesehatan Andalas. 2(2):240.

Forget, P., Khalifa, C., Defour, J. P., Latinne, D., Van Pel, M. C., & De Kock, M. (2017). What is the normal value of the neutrophil-to-lymphocyte ratio?. BMC research notes, 10, 1-4.

Gezer, C., Ekin, A., Ertas, I. E., Ozeren, M., Solmaz, U., Mat, E., & Taner, C. E. (2016). High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia. Ginekologia polska, 87(6), 431-435.

Gogoi, P., Sinha, P., Gupta, B., Firmal, P., & Rajaram, S. (2019). Neutrophil‐to‐lymphocyte ratio and platelet indices in pre‐eclampsia. International Journal of Gynecology & Obstetrics, 144(1), 16-20.

Gustri, Y., Sitorus, R. J., & Utama, F. (2016). Determinan kejadian preeklampsia pada ibu hamil di RSUP Dr. Mohammad Hoesin Palembang. Jurnal Ilmu Kesehatan Masyarakat, 7(3).

Hermawati, D. (2020). Hubungan Paritas dan Usia Ibu Hamil dengan Preeklampsia di Rumah Sakit Kota Banda Aceh. Idea Nursing Journal, 11(3), 62-69.

Hidayat, Akbar AN, Rosyid MIA, Nur A. (2018). Gawat Darurat Medis dan Bedah. Surabaya. pp. 197.

Himpunan Kedokteran Fetomaternal Indonesia. (2021). Konferensi Virtual Ke-1 HKFM Indonesia.

Hutabarat, R. A., Suparman, E., & Wagey, F. (2016). Karakteristik pasien dengan preeklampsia di RSUP Prof. Dr. RD Kandou Manado. e-CliniC, 4(1).

Kang, Q., Li, W., Yu, N., Fan, L., Zhang, Y., Sha, M., ... & Chen, S. (2020). Predictive role of neutrophil-to-lymphocyte ratio in preeclampsia: A meta-analysis including 3982 patients. Pregnancy hypertension, 20, 111-118.

Keman, K. (2014). Patomekanisme preeklampsia terkini: Mengungkapkan teori-teori terbaru tentang patomekanisme preeklampsia dilengkapi dengan deskripsi biomolekuler. Universitas Brawijaya Press.

Kholief, A., Swilam, R., Elhabashy, A., & Elsherief, R. (2019). Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and c-reactive protein as markers for severity of pre-eclampsia. Research and Opinion in Anesthesia & Intensive Care, 6(1), 1-8.

Kurniawati, D., Septiyono, E. A., Juliningrum, P. P., & Rahmawati, I. (2019). Analysis Characteristics of Pregnant Mother With Preeclampsia in Agronursing Area. Journal Of Nursing Practice, 3(1), 33-38.

Kurtoglu, E., Kokcu, A., Celik, H., Tosun, M., & Malatyalioglu, E. (2015). May ratio of neutrophil to lymphocyte be useful in predicting the risk of developing preeclampsia? A pilot study. The journal of maternal-fetal & neonatal medicine, 28(1), 97-99.

Kusumawati, W., & Wijayanti, A. R. (2019). Gambaran Faktor-Faktor Risiko Kejadian Preeklampsia Pada Ibu Bersalin dengan Preeklampsia (Di RS Aura Syifa Kabupaten Kediri bulan Februari–April tahun 2016). Jurnal Kebidanan, 6(2), 139-146.

Lee, J. S., Kim, N. Y., Na, S. H., Youn, Y. H., & Shin, C. S. (2018). Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea. Medicine, 97(26), e11138.

Lombo, G. E., Wagey, F. W., & Mamengko, L. (2017). KARAKTERISTIK IBU HAMIL DENGAN PREEKLAMSIADI RSUP PROF. DR. RD KANDOU MANADO PERIODE 1 JANUARI-31 DESEMBER 2015. JKK (Jurnal Kedokteran Klinik), 1(3), 9-15.

Mamlukah, M., & Saprudin, A. (2018). Gambaran Karakteristik Ibu Hamil Dengan Risiko Preeklampsia (Studi di Puskesmas Kabupaten Majalengka). Jurnal Ilmu Kesehatan Bhakti Husada: Health Sciences Journal, 9(2), 8-16.

Oylumlu, M., Ozler, A., Yildiz, A., Oylumlu, M., Acet, H., Polat, N., ... & Ertas, F. (2014). New inflammatory markers in pre-eclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio. Clinical and experimental hypertension, 36(7), 503-507.

Panwar, M., Kumari, A., Arora, R., Singh, V., & Bansiwal, R. (2019). Raised neutrophil lymphocyte ratio and serum beta hCG level in early second trimester of pregnancy as predictors for development and severity of preeclampsia. Drug discoveries & therapeutics, 13(1), 34-37.

Prasetyo, A., Bororing, S. R., & Sukadarma, Y. (2021). Neutrophil to lymphocyte ratio in Preeclampsia. Indonesian Journal of Obstetrics and Gynecology, 115-118.

Purwaningtyas ML, Prameswari GN. (2017). Kejadian Preeklampsia pada Ibu Bersalin Renita. Higeia Journal of Public Health Research and Development.1(3):84–94.

Putri HM, Andajani S, Nuswantoro D. (2015). Karakteristik Ibu Hamil Dengan Preeklampsia Dan Eklampsia Di Rsud Dr Soetomo Surabaya Periode Januari 2012 Hingga Desember 2012. Jurnal Ilmu Mahasiswa Kedokteran Universitas Airlangga. 7(7):25–31.

Riandy, M. D., Purba, B. A., Puspita, Y., Zainal, R., & Siswo, L. (2019). Hubungan Rasio Neutrofil Limfosit dengan Mortalitas≤ 28 hari di General Intensive Care Unit RSUP Dr. Mohammad Hoesin Palembang. Jurnal Anestesi Perioperatif, 7(3), 188-197.

Saputra, I. Y., Gustawan, W., Utama, M. D., & Arhana, B. (2019). Rasio neutrofil dan limfosit (NLCR) Sebagai faktor risiko terjadinya infeksi bakteri di ruang rawat anak RSUP Sanglah Denpasar. Sari Pediatri, 20(6), 354-9.

Serin, S., Avcı, F., Ercan, O., Köstü, B., Bakacak, M., & Kıran, H. (2016). Is neutrophil/lymphocyte ratio a useful marker to predict the severity of pre-eclampsia?. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 6(1), 22-25.

Setyawati, A., Widiasih, R., & Ermiati, E. (2018). Faktor-faktor yang berhubungan dengan kejadian preeklampsia di Indonesia. Jurnal Perawat Indonesia, 2(1), 32-40.

Singgih, R., Firmansyah, Y., & Dewi, A. K. (2020, September). Kemampuan klinis neutrophil lymphocyte ratio (NLR) pada kehamilan sebagai prediktor preeklamsia. In Prosiding Seminar Nasional Biologi (Vol. 6, No. 1, pp. 325-333).

Singhal, K., Pal, A. K., Tiwari, S., Singh, R., & Kushwaha, R. (2019). Neutrophil lymphocyte ratio (NLR) as a bio inflammatory marker in pre-eclampsia. Int J Contemp Med Res, 6(4), 4-6.

Sweed, M., Maqlad, A. H. M. E. D., & Kamel, O. (2021). The Accuracy of Neutrophil/Lymphocyte Ratio in Prediction of Preeclampsia in Low Risk Population. Evidence Based Women's Health Journal, 11(3), 248-255.

Toptas, M., Asik, H., Kalyoncuoglu, M., Can, E., & Can, M. M. (2016). Are neutrophil/lymphocyte ratio and platelet/lymphocyte ratio predictors for severity of preeclampsia?. Journal of Clinical Gynecology and Obstetrics, 5(1), 27-31.

Trisetiyaningsih Y, Smaradika A. (2019). Gambaran Karakteristik Ibu Hamil Yang Mengalami Preeklampsia. Media Ilmu Kesehatan. 7(3):238–43.

Widyastiti N, Setianingrum E. (2019). Perbedaan Antara Rasio Neutrofil / Limfosit Dan Rasio Platelet / Limfosit Pada Kehamilan Normal, Preeklampsia Ringan Dan Berat. Cendana Medical Journal. 17 (2014)334–40.

Wulandari, T. G. (2019). Rasio Neutrofil Limfosit Sebagai Prediktor Tingkat Keparahan Stroke Iskemik. Jurnal Ilmiah Kesehatan Sandi Husada, 8(2), 217-221.

Yavuzcan, A., Caglar, M., Ustun, Y., Dilbaz, S., Yidiz, E., Ozbilgec, S., ... & Ozdemir, I. (2014). Mean platelet volume, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in severe preeclampsia. Ginekologia polska, 85(3).

Zam N, Kumaladewi H, Dwi A, Rusman P. (2021). Faktor Faktor yang berhubungan dengan Preeklampsia Factors Related to the Incidence of Preeclampsia of Pregnancy in the Andi Makkasau Hospital of Parepare City. 4(1).

Published

2025-05-31

How to Cite

Ayuni, I. N., Yeni, C. M., Husnah, H., & Sakdiah, S. (2025). The Relationship between the Ratio of Neutrophil and Lymphocyte in Preeclampsia Patients. Asian Journal of Healthcare Analytics, 4(1), 153–166. https://doi.org/10.55927/ajha.v4i1.14391

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Articles