Evaluation of Antibiotic Use in Patients with Acute Appendicitis

Authors

  • Romauli Lumbantobing Department of Pharmacology & Therapy, Faculty of Medicine, Universitas Kristen Indonesia
  • Lidwindy Morani Logo Ule Clinical Student, Faculty of Medicine, Universitas Kristen Indonesia
  • Nur Nunu Prihantini Department of Biochemistry, Faculty of Medicine, Universitas Kristen Indonesia

DOI:

https://doi.org/10.55927/ajha.v5i1.16522

Keywords:

Acute Appendicitis, Antibiotics, Evaluation of Use, Gyssens Method

Abstract

This activity aims to evaluate the accuracy of antibiotic use among patients with acute appendicitis at Aeramo Regional General Hospital to support rational healthcare services. The process involved observing medical records from April 2024 to April 2025. The implementation method used a qualitative descriptive analysis based on Gyssens' criteria to assess indications, dosages, routes, and timing of administration in accordance with ASHP and IDSA guidelines. Evaluation results showed that 53% of antibiotic use was rational (Category 0), though inaccuracies in indications remained at 33%, particularly in non-perforation cases. Consequently, strengthening compliance with local clinical protocols is essential to prevent the risk of antimicrobial resistance within the hospital environment.

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References

Anggraini, W., Wiraningtias, N. B., Inayatilah, F. R., & Indrawijaya, Y. Y. A. (2020). Evaluasi penggunaan antibiotik pada pasien pasca bedah apendisitis akut di RSUD Kabupaten Pasuruan tahun 2018 (penelitian dilakukan di Instalasi Rawat Inap RSUD Kabupaten Pasuruan. Pharmaceutical Journal of Indonesia, 6(1), 15-20.

Bhangu, A., Søreide, K., Di Saverio, S., Assarsson, J. H., & Drake, F. T. (2015). Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. The Lancet, 386(10000), 1278-1287.

Bratzler, D. W., Dellinger, E. P., Olsen, K. M., Perl, T. M., Auwaerter, P. G., Bolon, M. K., ... & Weinstein, R. A. (2013). Clinical practice guidelines for antimicrobial prophylaxis in surgery. American journal of health-system pharmacy, 70(3), 195-283.

Fitriani, B. S., Angin, M. P., & Lestari, Y. E. (2024). Evaluasi Penggunaan Obat Pada Pasien Apendisitis Di Rumah Sakit Imanuel Way Halim Periode Tahun 2022. Jurnal Ilmu Kedokteran dan Kesehatan, 11(8), 1609-1614.

Guan L, Liu Z, Pan G, et al. The global, regional, and national burden of appendicitis in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019. BMC Gastroenterol [homepage on the Internet] 2023 [cited 2025 Nov 27];23(1). Available from: https://doi.org/10.1186/s12876-023-02678-7

Han H, Letourneau ID, Abate YH, et al. Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 2021. Lancet Gastroenterol Hepatol 2024;9(9):825–858.

Happyanto, M. R., Adhika, O. A., & Pranoto, D. (2022). An overview of patients of appendicitis and surgical site infection postappendectomy at Bethesda Hospital Yogyakarta period 2019-2020. Journal of Medicine and Health, 4(2), 154-164.

Harartasyahrani RA, Simamora S. Evaluasi Penggunaan Antibiotik Profilaksis pada Pasien Bedah Kategori Highly Recommended di Rumah Sakit ‘X’ Kota Prambulih. Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan 2021;5(1):121–30.

Maulana, E., & Salsabila, A. S. (2022). Hubungan Diagnosa Apendisitis Akut Dengan Jumlah Leukosit Di Rumah Sakit Muhammadiyah Palembang. Syaifa’MEDIKA, 12.

Maulina, K., Millizia, A., & Yuziani, Y. (2025). Gambaran Penggunaan Antibiotik Profilaksis pada Pasien Bedah Appendicitis di Rumah Sakit Arun Lhokseumawe Tahun 2020-2022. Inovasi Kesehatan Global, 2(4), 16-23.

Purnamasari, R., Syahruddin, F. I., Dirgahayu, A. M., Iskandar, D., & Fadhila, F. (2023). Karakteristik klinis penderita apendisitis. UMI Medical Journal, 8(2), 117-126.

Putri, D. A., Ramadhan, A. M., & Aryati, F. (2022). Pola penggunaan antibiotik pada pasien bedah apendiktomi berdasarkan ATC/DDD di RSUD Kanujoso Djatiwibowo Balikpapan. Prosiding Konferensi Farmasi Mulawarman, 15, 35-41.

Solomkin, J. S., Mazuski, J. E., Bradley, J. S., Rodvold, K. A., Goldstein, E. J., Baron, E. J., ... & Bartlett, J. G. (2010). Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clinical infectious diseases, 50(2), 133-164.

Sophia, A., Mustaqim, M. H., & Rizal, F. (2020). Perbandingan kadar leukosit darah pada pasien apendisitis akut dan apendisitis perforasi di RSUD Meuraxa Banda Aceh. Jurnal Ilmu Kedokteran dan Kesehatan, 7(3).

Wendari, A., Kusumajaya, H., & Faizal, K. M. (2025). Faktor-faktor yang berhubungan dengan kejadian penyakit apendisitis di Rumah Sakit Bakti Timah Pangkalpinang tahun 2023. Jurnal Kesehatan Tambusai, 6(1), 1252-1260.

Wendari, A., Kusumajaya, H., & Faizal, K. M. (2025). Faktor-faktor yang berhubungan dengan kejadian penyakit apendisitis di Rumah Sakit Bakti Timah Pangkalpinang tahun 2023. Jurnal Kesehatan Tambusai, 6(1), 1252-1260.

Published

2026-05-25

How to Cite

Lumbantobing, R. ., Ule, L. M. L. ., & Prihantini, N. N. . (2026). Evaluation of Antibiotic Use in Patients with Acute Appendicitis. Asian Journal of Healthcare Analytics, 5(1), 201–218. https://doi.org/10.55927/ajha.v5i1.16522

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Section

Articles