An Oral Microbiome Perspective: Postbiotics as a Prospective Therapeutic Agents in Dental Medicine (A Short Communication)
DOI:
https://doi.org/10.55927/fjsr.v3i11.12097Keywords:
Postbiotics, Oral Microbes, Biofilm, Probiotics, Oral HealthAbstract
Recently, there has been an increase in interest in the use of microorganisms that are used as a preventive effort to prevent dental and oral health problems, known as probiotics, prebiotics, synbiotics, and postbiotics. As more and more clinical trials of the use of microorganisms show positive results for certain conditions, Postbiotics have several advantages, including safety, longer shelf life, absence of risk and patentability, which makes them more attractive than probiotics. This review covers a wide range of aspects, starting with an introduction, terminology, role of post biotik, and a brief mechanism of action. The discovery section concludes by highlighting the challenges and future directions to improve postbiotic discovery. The review concludes by highlighting the ongoing applications of postbiotics in expanded clinical trials, providing a comprehensive overview of the current landscape in postbiotic development
Downloads
References
Adiningrat, A., Kusnadi, R. A., Allam, A. S., Sofiani, E., Maulana, I., & Yumoto, H. (2023). The Effect of Probiotic Lactobacillus acidophilus and Ethanolic Propolis Compound toward Nucleic Acid Deposition in the Extracellular Polymeric Substance of Root Canal Bacteria. European Journal of Dentistry, 17(02), 418–423. https://doi.org/10.1055/s-0042-1750771
Babu, A. S., Guruprasath, N., Adeyeye, S. A. O., Sankarganesh, P., Kumar, A. G., & Sivapriya, T. (2023). A Critical Analysis of Postbiotics: Exploring their Potential Impact on the Health and Food Industries. Journal of Pure and Applied Microbiology, 17(4), 2041–2059. https://doi.org/10.22207/JPAM.17.4.18
Barcenilla, A., Pryde, S. E., Martin, J. C., Duncan, S. H., Stewart, C. S., Henderson, C., & Flint, H. J. (2000). Phylogenetic Relationships of Butyrate-Producing Bacteria from the Human Gut. Applied and Environmental Microbiology, 66(4), 1654–1661. https://doi.org/10.1128/AEM.66.4.1654-1661.2000
Beattie, R. E. (2024). Probiotics for oral health: A critical evaluation of bacterial strains. Frontiers in Microbiology, 15, 1430810. https://doi.org/10.3389/fmicb.2024.1430810
Butera, A., Gallo, S., Pascadopoli, M., Taccardi, D., & Scribante, A. (2022). Home Oral Care of Periodontal Patients Using Antimicrobial Gel with Postbiotics, Lactoferrin, and Aloe Barbadensis Leaf Juice Powder vs. Conventional Chlorhexidine Gel: A Split-Mouth Randomized Clinical Trial. Antibiotics, 11(1), 118. https://doi.org/10.3390/antibiotics11010118
Chung, I.-C., OuYang, C.-N., Yuan, S.-N., Lin, H.-C., Huang, K.-Y., Wu, P.-S., Liu, C.-Y., Tsai, K.-J., Loi, L.-K., Chen, Y.-J., Chung, A.-K., Ojcius, D. M., Chang, Y.-S., & Chen, L.-C. (2019). Pretreatment with a Heat-Killed Probiotic Modulates the NLRP3 Inflammasome and Attenuates Colitis-Associated Colorectal Cancer in Mice. Nutrients, 11(3), 516. https://doi.org/10.3390/nu11030516
Deshpande, G., Athalye-Jape, G., & Patole, S. (2018). Para-probiotics for Preterm Neonates-The Next Frontier. Nutrients, 10(7), 871. https://doi.org/10.3390/nu10070871
Doyle, L., & Wang, M. (2019). Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis. Cells, 8(7), 727. https://doi.org/10.3390/cells8070727
Elson, C. O., & Cong, Y. (2012). Host-microbiota interactions in inflammatory bowel disease. Gut Microbes, 3(4), 332–344. https://doi.org/10.4161/gmic.20228
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., Verbeke, K., & Reid, G. (2017). Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology, 14(8), 491–502. https://doi.org/10.1038/nrgastro.2017.75
Homayouni Rad, A., Aghebati Maleki, L., Samadi Kafil, H., Fathi Zavoshti, H., & Abbasi, A. (2020). Postbiotics as novel health-promoting ingredients in functional foods. Health Promotion Perspectives, 10(1), 3–4. https://doi.org/10.15171/hpp.2020.02
Kessler, S. Q. S., Lang, P. M., Dal-Pizzol, T. S., & Montagner, F. (2022). Resistance profiles to antifungal agents in Candida albicans isolated from human oral cavities: Systematic review and meta-analysis. Clinical Oral Investigations, 26(11), 6479–6489. https://doi.org/10.1007/s00784-022-04716-2
Laverde Gomez, J. A., Mukhopadhya, I., Duncan, S. H., Louis, P., Shaw, S., Collie‐Duguid, E., Crost, E., Juge, N., & Flint, H. J. (2019). Formate cross‐feeding and cooperative metabolic interactions revealed by transcriptomics in co‐cultures of acetogenic and amylolytic human colonic bacteria. Environmental Microbiology, 21(1), 259–271. https://doi.org/10.1111/1462-2920.14454
Lemoine, A., Tounian, P., Adel-Patient, K., & Thomas, M. (2023). Pre-, pro-, syn-, and Postbiotics in Infant Formulas: What Are the Immune Benefits for Infants? Nutrients, 15(5), 1231. https://doi.org/10.3390/nu15051231
Lin, C.-W., Chen, Y.-T., Ho, H.-H., Kuo, Y.-W., Lin, W.-Y., Chen, J.-F., Lin, J.-H., Liu, C.-R., Lin, C.-H., Yeh, Y.-T., Chen, C.-W., Huang, Y.-F., Hsu, C.-H., Hsieh, P.-S., & Yang, S.-F. (2022). Impact of the food grade heat-killed probiotic and postbiotic oral lozenges in oral hygiene. Aging, 14(5), 2221–2238. https://doi.org/10.18632/aging.203923
Liu, Y., Wang, J., & Wu, C. (2021). Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics. Frontiers in Nutrition, 8, 634897. https://doi.org/10.3389/fnut.2021.634897
Luo, S.-C., Wei, S.-M., Luo, X.-T., Yang, Q.-Q., Wong, K.-H., Cheung, P. C. K., & Zhang, B.-B. (2024). How probiotics, prebiotics, synbiotics, and postbiotics prevent dental caries: An oral microbiota perspective. NPJ Biofilms and Microbiomes, 10(1), 14. https://doi.org/10.1038/s41522-024-00488-7
Ma, L., Tu, H., & Chen, T. (2023). Postbiotics in Human Health: A Narrative Review. Nutrients, 15(2), 291. https://doi.org/10.3390/nu15020291
Maleki, A., Hasannezhad, P., Abbasi, A., & Khani. (2021). Antibacterial, Antiviral, Antioxidant, and Anticancer Activities of Postbiotics: A review of Mechanisms and Therapeutic Perspectives. Biointerface Research in Applied Chemistry, 12(2), 2629–2645. https://doi.org/10.33263/BRIAC122.26292645
McFarland, L. V. (2006). Meta-Analysis of Probiotics for the Prevention of Antibiotic Associated Diarrhea and the Treatment of Clostridium difficile Disease. The American Journal of Gastroenterology, 101(4), 812–822. https://doi.org/10.1111/j.1572-0241.2006.00465.x
Nataraj, B. H., Ali, S. A., Behare, P. V., & Yadav, H. (2020). Postbiotics-parabiotics: The new horizons in microbial biotherapy and functional foods. Microbial Cell Factories, 19(1), 168. https://doi.org/10.1186/s12934-020-01426-w
Nunpan, S., Suwannachart, C., & Wayakanon, K. (2019). Effect of Prebiotics-Enhanced Probiotics on the Growth of Streptococcus mutans. International Journal of Microbiology, 2019, 4623807. https://doi.org/10.1155/2019/4623807
Piqué, N., Berlanga, M., & Miñana-Galbis, D. (2019). Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview. International Journal of Molecular Sciences, 20(10), 2534. https://doi.org/10.3390/ijms20102534
Qiao, X., Tang, J., Dou, L., Yang, S., Sun, Y., Mao, H., & Yang, D. (2023). Dental Pulp Stem Cell-Derived Exosomes Regulate Anti-Inflammatory and Osteogenesis in Periodontal Ligament Stem Cells and Promote the Repair of Experimental Periodontitis in Rats. International Journal of Nanomedicine, Volume 18, 4683–4703. https://doi.org/10.2147/IJN.S420967
Saïz, P., Taveira, N., & Alves, R. (2021). Probiotics in Oral Health and Disease: A Systematic Review. Applied Sciences, 11(17), 8070. https://doi.org/10.3390/app11178070
Salminen, S., Collado, M. C., Endo, A., Hill, C., Lebeer, S., Quigley, E. M. M., Sanders, M. E., Shamir, R., Swann, J. R., Szajewska, H., & Vinderola, G. (2021). The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nature Reviews. Gastroenterology & Hepatology, 18(9), 649–667. https://doi.org/10.1038/s41575-021-00440-6
Scott, E., De Paepe, K., & Van De Wiele, T. (2022). Postbiotics and Their Health Modulatory Biomolecules. Biomolecules, 12(11), 1640. https://doi.org/10.3390/biom12111640
Swanson, K. S., Gibson, G. R., Hutkins, R., Reimer, R. A., Reid, G., Verbeke, K., Scott, K. P., Holscher, H. D., Azad, M. B., Delzenne, N. M., & Sanders, M. E. (2020). The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nature Reviews Gastroenterology & Hepatology, 17(11), 687–701. https://doi.org/10.1038/s41575-020-0344-2
Szydłowska, A., & Sionek, B. (2022). Probiotics and Postbiotics as the Functional Food Components Affecting the Immune Response. Microorganisms, 11(1), 104. https://doi.org/10.3390/microorganisms11010104
Van Holm, W., Lauwens, K., De Wever, P., Schuermans, A., Zayed, N., Pamuk, F., Saghi, M., Fardim, P., Bernaerts, K., Boon, N., & Teughels, W. (2023). Probiotics for oral health: Do they deliver what they promise? Frontiers in Microbiology, 14, 1219692. https://doi.org/10.3389/fmicb.2023.1219692
Vera-Santander, V. E., Hernández-Figueroa, R. H., Jiménez-Munguía, M. T., Mani-López, E., & López-Malo, A. (2023). Health Benefits of Consuming Foods with Bacterial Probiotics, Postbiotics, and Their Metabolites: A Review. Molecules, 28(3), 1230. https://doi.org/10.3390/molecules28031230
Wegh, C. A. M., Geerlings, S. Y., Knol, J., Roeselers, G., & Belzer, C. (2019). Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond. International Journal of Molecular Sciences, 20(19), 4673. https://doi.org/10.3390/ijms20194673
Xie, W., Zhong, Y.-S., Li, X.-J., Kang, Y.-K., Peng, Q.-Y., & Ying, H.-Z. (2024). Postbiotics in colorectal cancer: Intervention mechanisms and perspectives. Frontiers in Microbiology, 15, 1360225. https://doi.org/10.3389/fmicb.2024.1360225
Yan, F., Liu, L., Dempsey, P. J., Tsai, Y.-H., Raines, E. W., Wilson, C. L., Cao, H., Cao, Z., Liu, L., & Polk, D. B. (2013). A Lactobacillus rhamnosus GG-derived Soluble Protein, p40, Stimulates Ligand Release from Intestinal Epithelial Cells to Transactivate Epidermal Growth Factor Receptor. Journal of Biological Chemistry, 288(42), 30742–30751. https://doi.org/10.1074/jbc.M113.492397
Żółkiewicz, J., Marzec, A., Ruszczyński, M., & Feleszko, W. (2020). Postbiotics—A Step Beyond Pre- and Probiotics. Nutrients, 12(8), 2189. https://doi.org/10.3390/nu1208218
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Aditya Rediana Friyandika, Luthfian Ibnu Afan
This work is licensed under a Creative Commons Attribution 4.0 International License.