Tangential role of therapeutics in COVID-19 induced Mucormycosis: A Review
DOI:
https://doi.org/10.55927/eajmr.v1i4.106Keywords:
Ayurved, Coronavirus associated Mucormycosis, Holistic Approach, Mucormycosis, Opportunistic FungiAbstract
Due to restricted treatment alternatives that were excessively expensive, people resorted to an integrated strategy with other relevant professions to reduce the burden on a single therapy. Objective: To estimate our ability to live with the limited disease load while reviewing the likely influence of holistic science on sustaining health dimensions. Method: PubMed, Google Scholar, and other embedded websites chose 205 Mucormycosis papers for examination, and 69 publications were chosen from diverse sources for the study. The study concentrated on clinical symptoms, risk factors for mortality, and future integrative therapeutic options, with a particular emphasis on Indian demographic data. Data were extracted from the study about India and Indian peoples based on descriptions and facts. Conclusion: Integrative preventive strategies and therapeutic approaches can reduce the burden on one drug and can prove cost-effective with better.
References
Alekseyev, K., Didenko, L., & Chaudhry, B. (2021). Rhinocerebral Mucormycosis and COVID-19 Pneumonia. Journal of Medical Cases, 12(3), 85–89. https://doi.org/10.14740/jmc3637
Amin, H., Sharma, R., Vyas, M., Prajapati, P. K., & Dhiman, K. (2014). Shankhapushpi (Convolvulus pluricaulis Choisy): Validation of the Ayurvedic therapeutic claims through contemporary studies. International Journal of Green Pharmacy, 8(4), 193–200.
https://doi.org/10.4103/0973-8258.142666
Anjali,Gunjan Sharma, P. B. (2016). Role Of Jalaukavacharana In Netra Roga. International Journal of Ayurveda and Pharma Research, 4(11), 75–77.
Ayurvedline. (2018). Pancha Tikta Ghrita Guggulu Health Benefits, Features and Doses. Ayurcentral Online. https://ayurcentralonline.com/en/blogs/100_panchatikta-ghritha-guggulu.html
Bala, K., Chander, J., Handa, U., Punia, R. S., & Attri, A. K. (2015). A prospective study of mucormycosis in north India: Experience from a tertiary care hospital. Medical Mycology, 53(3), 248–257. https://doi.org/10.1093/mmy/myu086
Balasopoulou, A., Κokkinos, P., Pagoulatos, D., Plotas, P., Makri, O. E., Georgakopoulos, C. D., Vantarakis, A., Li, Y., Liu, J. J., Qi, P., Rapoport, Y., Wayman, L. L., Chomsky, A. S., Joshi, R. S., Press, D., Rung, L., Ademola-popoola, D., Africa, S., Article, O., … Loukovaara, S. (2017).
Symposium Recent advances and challenges in the management of retinoblastoma Globe ‑ saving Treatments. BMC Ophthalmology, 17(1), 1. https://doi.org/10.4103/ijo.IJO
Boelaert, J. R., Fenves, A. Z., & Coburn, J. W. (1991). Deferoxamine Therapy and Mucormycosis in Dialysis Patients: Report of an International Registry. American Journal of Kidney Diseases, 18(6), 660–667. https://doi.org/10.1016/S0272-6386(12)80606-8
Boelaert JR, de Locht M, Van Cutsem J, Kerrels V, Cantinieaux B, Verdonck A, Van Landuyt HW, S. Y. (n.d.). Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies. J Clin Invest, 91(5), 1979–1986. https://doi.org/10.1172/JCI116419
Chainani, S., Siddana, S., Reddy, C. V., Thippeswamy, M., Maurya, M., & Rudraswamy, S. (2015). Antimicrobial activity of Triphala on Lactobacilli and Candida albicans: An in vitro study. Journal of Orofacial Sciences, 7(2), 104–107. https://doi.org/10.4103/0975-8844.169757
Chakrabarti, A., Chatterjee, S. S., Das, A., Panda, N., Shivaprakash, M. R., Kaur, A., Varma, S. C., Singhi, S., Bhansali, A., & Sakhuja, V. (2009). Invasive zygomycosis in India: Experience in a tertiary care hospital. Postgraduate Medical Journal, 85(1009), 573–581. https://doi.org/10.1136/pgmj.2008.076463
Chakrabarti, A., & Sakhuja, V. (2001). Ten years experience in zygomycosis at a tertiary care centre in India. Journal of Infection, 42(4), 261–266. https://doi.org/10.1053/jinf.2001.0831
Chakrabarti, Arunaloke, Das, A., Mandal, J., Shivaprakash, M. R., George, V. K., Tarai, B., Rao, P., Panda, N., Verma, S. C., & Sakhuja, V. (2006). The rising trend of invasive zygomycosis in patients with uncontrolled diabetes mellitus. Medical Mycology, 44(4), 335–342. https://doi.org/10.1080/13693780500464930
Chakrabarti, Arunaloke, & Singh, R. (2014). Mucormycosis in India: Unique features. Mycoses, 57(s3), 85–90. https://doi.org/10.1111/myc.12243
Chander, J., Kaur, M., Singla, N., Punia, R. P. S., Singhal, S. K., Attri, A. K., Alastruey-Izquierdo, A., Stchigel, A. M., Cano-Lira, J. F., & Guarro, J. (2018). Mucormycosis: Battle with the deadly enemy over a five-year period in India. Journal of Fungi, 4(2). https://doi.org/10.3390/jof4020046
Choudhary, S. R. (2021). India authorities warn of rare fungal infection seen in some COVID-19 patients. CNBC. https://www.cnbc.com/2021/05/11/india-covid-crisis-mucormycosis-fungal-infection.html
Dabur, R., Singh, H., Chhillar, A. K., Ali, M., & Sharma, G. L. (2004). Antifungal potential of Indian medicinal plants. Fitoterapia, 75(3–4), 389–391. https://doi.org/10.1016/j.fitote.2004.01.015
Dawane, J. S., Pandit, V. A., Bhosale, M. S. K., & Khatavkar, P. S. (2016). Evaluation of effect of Nishamalaki on STZ and HFHF diet induced diabetic neuropathy in wistar rats. Journal of Clinical and Diagnostic Research, 10(10), FF01–FF05.
https://doi.org/10.7860/JCDR/2016/21011.8752
Debjit Bhowmik, Chiranjib, J. Y. et al. (2010). Herbal Remedies of Azadirachta indica and its Medical application. Journal of Chemical and Pharmaceutical Research, 2(1), 62–72. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/viewer.html?pdfurl=https%3A%2F%2Fwww.jocpr.com%2Farticles%2Fherbal-remedies-of-azadirachta-indica-and-its-medicinal-application.pdf&clen=109082&chunk=true
Dr.Jv.Habber. (2012). Madhu Snuhi Rasayanam Uses, Doses,Side-effects, Ingredients. Ayurmed Info. https://www.ayurmedinfo.com/2012/02/11/madhusnuhi-rasayanam-uses-dose-side-effects-ingredients/
Dr.Jv Habber. (2012). Navratna Raja Mriganka Rasa, Benefits, doses, ingredients, Side-Effects. Ayurmed Info. ayurmedinfo.com/2012/07/10/navaratna-raja-mriganka-rasa-benefits-dosage-ingredients-side-effects/
Dr.L.Mahadevan, Dr.G.Aishwarya, D. V. C. (2021). Mucormycosis: A Conceptual Ayurvedic Approach (04652282239/282449/9751691516).
Dr.Ritika Shah, Dr.Ekta Tomar, D. N. S. (2017). Anti-Fungal Activity of Arka Tail. International Journal of Ayurvedic and Herbal Medicine, 4(7), 2852–2855. https://doi.org/10.18535/ijahm/v7i4.31
Dr. Sunil Kumar Mishra. (2020). World Diabetes Day: Why is India the World Capital for Diabetes? India Today News. https://www.indiatoday.in/information/story/world-diabetes-day-why-is-india-the-world-capital-for-diabetes-1740874-2020-11-14
Espinel-Ingroff, A., & Dannaoui, E. (2021). Special issue: Antifungal agents recently approved or under development. Journal of Fungi, 7(3), 10–11. https://doi.org/10.3390/jof7030239
G.Vyas, D. A. (2020). Understanding of Infectious Disease as per Ayurvedic Perspective-A Simplified Review. Journal of Ayurveda and Integrated Medical Sciences, 5(April), 1. https://www.jaims.in/jaims/article/view/822
Gautam, A. K., Avasthi, S., Sharma, A., & Bhadauria, R. (2012). Antifungal potential of triphala churna ingredients against Aspergillus species associated with them during storage. In Pakistan Journal of Biological Sciences (Vol. 15, Issue 5, pp. 244–249). https://doi.org/10.3923/pjbs.2012.244.249
Ghadage, V. S. H., & Landge, V. A. C. (2020). MUKHAPAKA WITH ITS MODERN ASPECT- A REVIEW LITERATURE. European Journal of Pharmaceutical and Medical Research, 7(7), 386–388. https://www.ejpmr.com/home/abstract_id/6941#:~:text=MUKHAPAKA WITH ITS MODERN ASPECT- A REVIEW LITERATURE&text=It refers to an oral, Anubandhirogam) other diseases like Grahani.
Gill Dimpal, M. R. R. (2020). View of Skin Infections In Diabetes Mellitus (DM) –A Review. International Journal of Ayurveda and Pharma Research, 8(1), 77–80. https://ijapr.in/index.php/ijapr/article/view/1350
Godbole, A. (2016). An Ayurvedic Concept for Prevention Is Better Than Cure. World Journal of Pharmacy and Pharmaceutical Sciences, 5(8), 414–420. https://doi.org/10.20959/wjpps20168-7317
Hebber, D. . v. (n.d.). Madhusnuhi Rasayanam Uses, Doses,Side-Effects, Ingredients. Ayurmed Info. Retrieved June 5, 2021, from https://www.ayurmedinfo.com/2012/02/11/madhusnuhi-rasayanam-uses-dose-side-effects-ingredients/
Kashyap, V., Gaur, M., Pandey, Y., & Sabharwal, P. (2019). Raktamokshan- an Ancient Ayurvedic Parasurgical Practice and Its Applicability in Contemporary Clinical Practice: a Review. European Journal of Pharmaceutical And Medical Research, 6(4), 634–640.
Kaushik Vilas Kulkarni, D. B. V. A. (2018). A review on Indian traditional shrub Tulsi (ocimum sanctum): The unique medicinal plant. Journal of Medicinal Plants Studies, 6(2), 106–110. chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/viewer.html?pdfurl=https%3A%2F%2Fwww.plantsjournal.com%2Farchives%2F2018%2Fvol6issue2%2FPartB%2F6-2-12-979.pdf&clen=737121&chunk=true
Kumar, S., Gurao, R. P., Namburi, U. S., Khode, N. V, & Mahulkar, D. M. (2020). Pathogenesis of COVID-19: A Review on Integrative Understanding through Ayurveda. Journal of Research in Ayurvedic Sciences, 4(3), 104–112. https://doi.org/10.5005/jras-10064-0110
Meena, A. K., Kaur, R., Singh, B., Yadav, A. K., Singh, U., Sachan, A., Pal, B., & Rao, M. M. (2010). Review on antifungal activities of Ayurvedic Medicinal Plants. Journal of Medicine (Cincinnati), 2(2), 146–148. https://www.semanticscholar.org/paper/Review-on-antifungal-activities-of-Ayurvedic-Plants-Meena-Kaur/25a2cb1faced8d082f329d8248255bd2c8e6b368
Meera, S., Vandana Rani, M., Sreedhar, C., & Robin, D. T. (2020). A review on the therapeutic effects of Neti Kriya with special reference to Jala Neti. Journal of Ayurveda and Integrative Medicine, 11(2), 185–189. https://doi.org/10.1016/j.jaim.2018.06.006
Meis, J. F., & Chakrabarti, A. (2009). Changing epidemiology of an emerging infection: Zygomycosis. In Clinical Microbiology and Infection (Vol. 15, Issue SUPPL. 5, pp. 10–14). https://doi.org/10.1111/j.1469-0691.2009.02973.x
Mohapatra, S., Jain, M., & Xess, I. (2010). Spectrum of zygomycoses in north India: An institutional experience. Indian Journal of Medical Microbiology, 28(3), 262. https://doi.org/10.4103/0255-0857.66471
Mukhapaka, M. O. F. (2019). A Study On The Efficacy Of Panchpallav Kwathwith Madhu In Management Of Mukhapaka. Global Journal For Research Analysis, 8(12), 15–17. https://doi.org/https://www.doi.org/10.36106/gjra
P.Chakraborty. (2005). Overview of Mycology. In D. M. Sen (Ed.), A Text Book of Microbiology (2005th ed., pp. 609–615). New Central Book Agency(P)Ltd.
Patel, A. K., Patel, K. K., Patel, K., Gohel, S., & Chakrabarti, A. (2017). Mucormycosis at a tertiary care centre in Gujarat, India. Mycoses, 60(6), 407–411. https://doi.org/10.1111/myc.12610
Patel, A., Kaur, H., Xess, I., Michael, J. S., Savio, J., Rudramurthy, S., Singh, R., Shastri, P., Umabala, P., Sardana, R., Kindo, A., Capoor, M. R., Mohan, S., Muthu, V., Agarwal, R., & Chakrabarti, A. (2019). A multicentre observational study on the epidemiology, risk factors, management and outcomes of mucormycosis in India. Clinical Microbiology and Infection, 7, 1–7. https://doi.org/10.1016/j.cmi.2019.11.021
Petrikkos, G., Skiada, A., Lortholary, O., Roilides, E., Walsh, T. J., & Kontoyiannis, D. P. (2012). Epidemiology and clinical manifestations of mucormycosis. Clinical Infectious Diseases, 54(SUPPL. 1), 23–34. https://doi.org/10.1093/cid/cir866
Prakash, H., & Chakrabarti, A. (2019). Global epidemiology of mucormycosis. Journal of Fungi, 5(1). https://doi.org/10.3390/jof5010026
Prakash, H., & Chakrabarti, A. (2021). Epidemiology of mucormycosis in India. Microorganisms, 9(3), 1–12.
https://doi.org/10.3390/microorganisms9030523
Prakash, H., Chakrabarti, A., Sipsas, N. V., Gamaletsou, M. N., Anastasopoulou, A., Kontoyiannis, D. P., Petrikkos, G., Skiada, A., Lortholary, O., Roilides, E., Walsh, T. J., Kontoyiannis, D. P., Sharma, S., Kaushal, J. C., Prasutitantra, O. F. S., SHABBIR, N., HASSAN, S. M., MUGHAL, S. S., PERVEIZ, S., … Guinea, J. (2018). Mucormycosis and entomophthoramycosis: A review of the clinical manifestations, diagnosis and treatment. Clinical Microbiology and Infection, 5(3), 23–34. https://doi.org/10.1111/j.1469-0691.2006.01604.x
Prakash, H., Ghosh, A. K., Rudramurthy, S. M., Singh, P., Xess, I., Savio, J., Pamidimukkala, U., Jillwin, J., Varma, S., Das, A., Panda, N. K., Singh, S., Bal, A., & Chakrabarti, A. (2019). A prospective multicenter study on mucormycosis in India: epidemiology, diagnosis, and treatment. Medical Mycology, 57(4), 395–402. https://doi.org/10.1093/mmy/myy060
Priya, P., Ganesan, V., Rajendran, T., & Geni, V. G. (2020). Mucormycosis in a tertiary care center in South India: A 4-year experience. Indian Journal of Critical Care Medicine, 24(3), 168–171. https://doi.org/10.5005/jp-journals-10071-23387
Pundge, S. J., & Kotangale, Y. T. (2015). Role of Jalaukavcharana in Netraroga. International Journal of Ayurvedic Medicine, 6(3), 202–205. https://doi.org/10.47552/ijam.v6i3.694
Roden, M. M., Zaoutis, T. E., Buchanan, W. L., Knudsen, T. A., Sarkisova, T. A., Schaufele, R. L., Sein, M., Sein, T., Chiou, C. C., Chu, J. H., Kontoyiannis, D. P., & Walsh, T. J. (2005). Epidemiology and outcome of zygomycosis: A review of 929 reported cases. Clinical Infectious Diseases, 41(5), 634–653. https://doi.org/10.1086/432579
Saokar, R. M., Sarashetti, R. S., Kanthi, V., Savkar, M., & Nagthan, C. V. (2013). Screening of Antibacterial and Antifungal Activity of Gandhaka Rasayana- an Ayurvedic Formulation. Int J Recent Trends Sci Technol, 8(2), 134–137.
Sethi, D., & Rajan, S. (2018). A Review Article On Raktamokshana And Its Mode of Action. International Journal of Panchakarma and Ayurved Medicine, 2(1), 95–102. http://www.ijpaam.com/uploads/jan-march-2018/7.pdf
Sharma, R., Amin, H., Ruknuddin, G., & Prajapati, P. (2015). Efficacy of Ayurvedic remedies in type 2 diabetes: A review through works done at Gujarat Ayurved University, Jamnagar. Journal of Medical Nutrition and Nutraceuticals, 4(2), 63. https://doi.org/10.4103/2278-019x.151812
Sharma, S., Grover, M., Bhargava, S., Samdani, S., & Kataria, T. (2021). Post coronavirus disease mucormycosis: a deadly addition to the pandemic spectrum. The Journal of Laryngology & Otology, May, 1–6. https://doi.org/10.1017/s0022215121000992
Shrestha, S., Bedarkar, P. B., & Chaudhari, S. Y. (2017). Dhoopana Karma : a Review Through Brihatrayi Dhoopana Karma : a Review Through Brihatrayi. International Ayurvedic Medical Journal, 1(3), 316–325.
Shukla, R., & Khuje, S. (2019). International Concept of Mukha Swasthya ( Oral Hygiene ) With Special Reference. International Ayurvedic Medical Journal, 3(3), 1643–1649. http://www.iamj.in/posts/images/upload/1644_1649.pdf
Singh, B., Gupta, V., Bansal, P., Kumar, D., & Krishna, C. M. (2011). Pharmacological Potential of Polyherbal Formulation, Sudarshan Churna – A Review. International Journal of Ayurvedic Medicine, 2(2). https://doi.org/10.47552/ijam.v2i2.39
Singh, J. (2014). Swarna Malini Vasant Ras Ingredients ( Composition ) Chronic fever. Ayur Times. https://www.ayurtimes.com/swarna-malini-vasant-ras/
Singh, N. A., Kumar, P., Jyoti, & Kumar, N. (2021). Spices and herbs: Potential antiviral preventives and immunity boosters during COVID-19. Phytotherapy Research, 35, 2745–2757. https://doi.org/10.1002/ptr.7019
Sipsas, N. V., Gamaletsou, M. N., Anastasopoulou, A., & Kontoyiannis, D. P. (2018). Therapy of mucormycosis. Journal of Fungi, 4(3), 1–17. https://doi.org/10.3390/jof4030090
Sipsas, N. V, Gamaletsou, M. N., Anastasopoulou, A., & Kontoyiannis, D. P. (n.d.). Therapy of Mucormycosis. https://doi.org/10.3390/jof4030090
Skiada.A.et.al. (2011). Zygomycosis in Europe: analysis of 230 cases accrued by the registry of the European Confederation of Medical Mycology (ECMM) Working Group on Zygomycosis between 2005 and 2007. Clinical Microbiology and Infection, 17, 1859–1867. https://doi.org/https://doi.org/10.1111/j.1469-0691.2010.03456.x
Spellberg, B., Andes, D., Perez, M., Anglim, A., Bonilla, H., Mathisen, G. E., Walsh, T. J., & Ibrahim, A. S. (2009). Safety and outcomes of open-label deferasirox iron chelation therapy for mucormycosis. Antimicrobial Agents and Chemotherapy, 53(7), 3122–3125. https://doi.org/10.1128/AAC.00361-09
Swagata Chakraborty, A. Das. (2020). A Classical Ayurveda Review On Haridra. Ayurdhara-An International Journal of Research in Ayush And Allied Systems, 7(1), 47–55. https://ayushdhara.in/index.php/ayushdhara/article/view/579/531
Tadasad, D. S., Katti, D. B. H., Sajjanshetti, D. M. R., & Kannolli, D. G. N. (2018). Concept of Rakta Dhatu w.s.r. to Rakta Pradoshaja Vikara. Journal of Ayurveda and Integrated Medical Sciences (JAIMS), 3(5), 187–197. https://doi.org/10.21760/jaims.v3i5.13842
Thakur, B. L., Paul, S. D., & Jain, A. K. (2021). Ayurveda Perspective On Covid-19, Fungal-Infections Associated With Disease And Possible Management : A Review. International Journal of Ayush, 10(01), 49–54.
Vaghela, D., Palmer, K., & Manjusha, R. (2011). A clinical study on the effect of Arka Taila in the management of Karnasrava (Otomycosis). AYU (An International Quarterly Journal of Research in Ayurveda), 32(3), 349. https://doi.org/10.4103/0974-8520.93912
Vasant Patil,Madhuri Rodd,Shruti Naik, M. K. (2020). Management Of Mucormycosis In Ayurveda : An Evidence Based Review. Journal of Ayurveda & Holistic Medicine Www.Jahm. Co.In, IX(II), 11–19. http://jahm.co.in/index.php/jahm/article/view/43
Vaughan, C., Bartolo, A., Vallabh, N., & Leong, S. C. (2018). A meta-analysis of survival factors in rhino-orbital-cerebral mucormycosis—has anything changed in the past 20 years? Clinical Otolaryngology, 43(6), 1454–1464. https://doi.org/10.1111/coa.13175
Wankhede, S. D., Kamble, N. K., & Khond, K. (2021). Ayurvedic Immunomodulation Therapy in Post Covid Care W.S.R To Pcfs Scale-a Single Case Report. International Ayurvedic Medical Journal, 09(3), 690–695. https://doi.org/10.46607/iamj3009032021
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