Type of Cosurfactant Effects on Particle Size in Nanoemulsion Drug Delivery Systems
DOI:
https://doi.org/10.55927/eajmr.v2i9.6276Keywords:
Nanoemulsion, Cosurfactant, Particle SizeAbstract
Nanoemulsions are thermodynamically or kinetically stable compared to conventional emulsions, and the particle size of nanoemulsions is around 5-200 nm. Until now, there has been no research comparing propylene glycol and PEG 400 cosurfactants for nanoemulsions, so it needs to be investigated. Laboratory experimental research with cosurfactant propylene glycol and PEG 400 Formula 1 and Formula 2 were repeated three times (n = 3) for each nanoemulsion formula. Parameters of physical properties (organoleptic, viscosity, particle size, index polydispersity) and chemical properties (pH). Evaluated and analyzed, <0.05 is considered significant. The results of formula 1 and formula 2 obtained the same clear organoleptic properties. The average particle size with cosurfactant propylene glycol was 10.41 ± 0.14 nm and PEG 400 was 12.32 ± 0.38 nm (p <0.05). The average viscosity, polydispersity index, and pH of propylene glycol were 8.72 ± 1.12; 0.03±0.02; 4.20 ± 0.04; and PEG 11.26 ± 1.80; 0.39 ± 0.58; 4.03±0.03. This shows that the type of cosurfactant has an effect on the size of the nanoemulsion particles.
References
Savjani, Ketan T., Anuradha K. Gajjar, and Jignasa K. Savjani. (2012). Drug Solubility: Importance and Enhancement Techniques. ISRN Pharmaceutics.
Kumar, R., Girish Chandra Soni, and S.K. Prajapati. (2017). Formulation Development and Evaluation of Telmisartan Nanoemulsion. Prajapati International Journal of Research and Development in Pharmacy & Life Science.
Shah, P., Bhalodia D, Shelat P. (2010). Nanoemulsion : A Pharmaceutical Review. Sys Rev Pharm :India.
Jusnita, N., Wan Syurya T., Maria Sergianika Perpetua Diaz. (2019). Formulasi Nanoemulsi Ekstrak Temulawak (Curcuma xanthorrhiza roxb) Dengan Metode Inversi Suhu. Jurnal Farmasi Higea.
Handayani, Fatimah Siyam, Bambang H. Nugroho, Siti Zahliyatul Munawiroh. (2018). Optimasi Formulasi Nanoemulsi Minyak Biji Anggur Energi Rendah dengan D-Optimal Mixture Design (DMD). Jurnal Ilmiah Farmasi.
Tadros, Tharwat F. (2005). E-book Applied Surfactants: Surfactants in Nanoemulsions First Edition. Weinheim: Wiley-VCH Verlag. Germany.
Devarajan, V., dan Ravichandran, V. (2011). Nanoemulsions : as modified drug delivery tool. International journal of comprehensive pharmacy.
Gupta, P.K., Pandit, J.K., Kumar, A., Swaroop, P., dan Gupta, S., (2010). Pharmaceutical nanotechnology Novel Nanoemulsion-High Energy Emulsification preparation, Evaluation, and Application. The Pharma Research.
Tungadi, Robert., (2020). Teknologi Nano Sediaan Liquida dan Semisolida. CV. Sagung Seto, 168-169 10. Williams, A.C. dan Barry B.W. (2007). Chemical Permeation Enhancement in Drug Delivery. New York. CRC Press.
Nayak, A.K., dan Panigrahi, P. (2012) Solubility Enhancement of Etoricoxib by Cosolvency Approach. ISRN Physical Chemistry.
Vemula, V.R, Lagishetty, V. Dan Lingala S. (2010). A review Articel : Solubility Enhancement Techniques. International Journal of Pharmaceutical Sciences Review and Research.
Sisak, M.A.A., Daik, R., R. S. (2017). Study on the effect of oil phase and cosurfactant on mcroemulsion system. Malaysian Journal of Analytical Sciences.
Nandi, I. Bateson, M. Bari, M. Joshi, H.N. (2003). Synergistic Effect of PEG-400 and Cyclodextrin to Enhance Solubility of Progesterone. AAPS PharmSciTech.
Nirmalayanti ,Ni Luh Putu Karunia Vidya. (2021). Skrining Berbagai Jenis Surfaktan Dan Kosurfaktan Sebagai Dasar Pemilihan Formulasi Nanoemulsi. Jurnal Ilmu Multidisiplin.
Nurhidayati, Lailiana Garna, Bambang Hernawan Nugroho, Oktavia Indrati. (2020). Formulasi dan Uji Sifat Fisik Sediaan Nanoemulsi Natrium Diklofenak dengan Kombinasi Tween 80 dan Transkutol. SAINTEKS.
Shakeel, F., Baboota, S., Ahuja, A., Ali, J., Aqil, M., and Shafiq, S. (2008). Stability evaluation of celecoxib nanoemulsion containing tween 80. Thai Journal Pharm.
Depkes RI. (2014). Farmakope Indonesia Edisi Kelima, Departemen Kesehatan Republik Indonesia. Jakarta.
Ma’arif, Burhan, Rani Azzahara, Fahrul Rizki, Arief Suryadinata, Abdul Wafi, Novia Maulina, Hajar Sugihantoro. (2023). Formulasi Dan Karakterisasi Nanoemulsi Ekstrak Etanol 70% Daun Semanggi (Marsilea crenata C. Presl.). Medical Sains : Jurnal Ilmiah Kefarmasian.
Devi, I Gusti Ayu Sri Krsna , Sri Mulyani, Lutfi Suhendra, (2019). Pengaruh Nilai Hydrophile-Liphophile Balance (HLB) dan Jenis Ekstrak terhadap Karakteristik Krim Kunyit-Lidah Buaya (Curcuma domestica val.- Aloe vera). Jurnal Ilmiah Teknologi Pertanian Agrotechno.
Ardian, G., Hajrah, Adam M Ramadhan., (2018). Formulasi Nanoemulsi dari Kombinasi Ekstrak Bunga Mawar dan Ekstrak Bengkoang dengan Pembawa Minyak Medium Chain Tryglicerides. Mulawarman Pharmaceuticals Conferences.
Ulya, M. Ridho, Indra Perdana, dan Panut Mulyono. (2017). Pengaruh Penambahan Surfaktan Sodium Lignosulfonat (SLS) dalam Proses Pengendapan Nano Calcium Silicate (NCS) dari Geothermal Brine. jurnal Rekayasa Proses.
Roosevelt, Alfreds, Sulfiyana H Ambo Lau, Hazhima Syawal. (2019). Formulasi dan Uji Stabilitas Krim Ekstrak Methanol Daun Beluntas (Pluchea indica l.) dari Kota Benteng Kabupaten Kepulauan Selayar Provinsi Sulawesi Selatan. Jurnal Farmasi Sandi Karsa.
Tanjung, Yenni P. (2013). Formulasi, evaluasi, serta uji sitotoksin terhadap sel kanker mcf-7 dari sistem nanopartikel polimerik polyvinyl pyrrolidone dengan zat aktif kurkumin. IJAS.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Ike Widyaningrum, Efriza Fahmi Triyoga, Nugroho Wibisono, Shinta Kusumawati, Anita Puspa Widiyana
This work is licensed under a Creative Commons Attribution 4.0 International License.
