Optimization and Characterization of Self Nano Emulsifying Drug Delivery System (SNEDDS) of Curcumin with D-Optimal Mixture Design Method

Authors

  • Mulyaningtyas Ayu Kusumawati Department of Pharmacy, Faculty of Pharmacy, Setiabudi University
  • Iswandi Iswandi Department of Pharmacy, Faculty of Pharmacy, Setiabudi University
  • Ilham Kuncahyo Department of Pharmacy, Faculty of Pharmacy, Setiabudi University

DOI:

https://doi.org/10.55927/eajmr.v3i11.12051

Keywords:

Curcumin, SNEDDS, Optimasi, D-Optimal Mixture Design

Abstract

Curcumin, known for its anti-inflammatory, antibacterial, anticarcinogenic, and antioxidant properties, faces challenges due to poor water solubility and low bioavailability as a BCS class II compound. The study investigates using a self-nanoemulsifying drug delivery system (SNEDDS) to enhance these properties, optimizing the formulation with the D-Optimal Mixture Design method. Sixteen formulas were prepared using oleic acid, Tween 80, and PEG 400. Each formula was characterized by particle size, % transmittance, emulsification time, and drug loading. The optimized formula, containing 10% oleic acid, 70% Tween 80, and 20% PEG 400, achieved a particle size of 80.167 nm, an emulsification time of 39.36 seconds, near 100% transmittance, and high drug loading.

References

A,R, Vaughn, A, Branum, R,K, Sivamani, Effects Of Turmeric (Curcuma Longa) On Skin Health: A Systematic Review Of The Clinical Evidence, Phytother, Res, 2015 (October) (2016) 1243–1264.

Azeem A, Rizwan M, Ahmad FJ, Khan ZI, Khar RK, Aqil M, 2008. Emerging Role Of Microemulsions In Cosmetics. Recent Patents On Drug Delivery & Formulation Volume 2 , Issue 3.

FHI, 2009, Indonesian Herbal Pharmacopoeia, Edition I, Jakarta: Ministry of Health of the Republic of Indonesia.

Jian Li, Ruixu Niu, Lixin Dong, Liming Gao, Jie Zhang, Yue Zheng, Ming Shi, Zhiwei Liu, Kun Li, "Nanoencapsulation Of Curcumin And Its Protective Effects Against Ccl4-Induced Hepatotoxicity In Mice", Journal Of Nanomaterials, Vol. 2019.

Khan, M,; Ali, M,; Shah,W,; Shah, A,; Yasinzai, M,M, Curcumin-Loaded Self-Emulsifying Drug Delivery System (Cu-SEDDS): A Promising Approach For The Control Of Primary Pathogen And Secondary Bacterial Infections In Cutaneous Leishmaniasis, Appl, Microbiol, Biotechnol, 2019, 103, 7481–7490

Kharia, A, A,, Singhai, A, K,, & Verma, R, 2012, Formulation And Evaluation Of Polymeric Nanoparticles Of An Antiviral Drug For Gastroretention, Int, J, Of Pharmaceutical Sci, And Nanotechnology, Vol, 4, Issue 4.

Ko, Jung & Park, Hyun. (2020). Preparation And Characterization Of Curcumin Solid Dispersion Using HPMC. Journal Of Food Science. 85. 3866-3873. 10.1111/1750-3841.15489.

Kommuru, T.R., Gurley, B., Khan, M.A., Reddy, I.K., 2001, Self-Emulsifying Drug Delivery Systems (SEDDS) Of Coenzyme Q10: Fomulation Development And Bioavaibility Assessment, Int. J. Pharm., 212, 233-246.

Kulac, M,, Aktas, C,, Tulubas, F, Et Al, The Effects Of Topical Treatment With Curcumin On Burn Wound Healing In Rats, J Mol Hist 44, 83–90 (2013).

Kuncahyo, Ilham & RSP, Pudiastuti, (2017), Development and Optimization of Self Microemulsion Drug Delivery System (SMEDDS) Formula of Curcumin to Increase Bioavailability, Indonesian Journal of Pharmacy, 14, 99-109.

Kusumawati, Anggun & Hutami, Siti, (2019), The Effect of Gelling Agent Carbopol 394 934 Ethanol Extract of Kaffir Lime Leaves (Citrus Hystrix Dc) on the Physical Properties of Gel and Antibacterial Activity of Staphylococcus Aureus, Pharma Xplore

M,M, Yallapu, P,K,B, Nagesh, M, Jaggi, S,C, Chauhan, Therapeutic Applications Of Curcumin Nanoformulations, AAPS J, 17 (6) (2015) 1341–1356.

Mahmoud H, Saleh A,, Elkadi S, Desaign And Optimization Of Selfnanoemulsifying Drug Delivery Systems Of Simvastatin Aiming Dissolution Enhancement, African Journal Of Pharmacy And Pharmacology, 2013 ; 1483

Martono, S,, 1996, Penentuan Kadar Kurkumin Secara Kromatografi Lapis Tipis Densitometri, Buletin ISFI, DIY 2 (4), 11-21

Mohanraj, V,J, And Y, Chen, 2006, Nanoparticles : A Review, Tropical Journal Of Pharmaceutical Research, 5 :1.

Morakul, B. (2020). Self-Nanoemulsifying Drug Delivery Systems (SNEDDS): An Advancement Technology For Oral Drug Delivery. Pharmaceutical Sciences Asia, 47(3), 205–220.

Muadifah, A,, Amalia, E,P,, Dan Nur, L, 2019, Activity of Turmeric Rhizome Extract Gel (Curcuma Domestica Val) Against Staphylococcus Aureus Bacteria, Jurnal Sainhealth, 3(1): 46.

Nakhil, U,, Kaltsum, U,, Purwojati, N,, Latifah, E,, 2018, Test Of Stability And Determination Of Optimum Formula On Gel Madam " Gel Adam Hawa Leaf Extracts ( Rheo Discolor ) As Antiinflamation Gel " For Advanced Research, Prosiding APC (Annual Pharmacy Conference), 3, 14–24.

Nandita, Sesilia & Kuncahyo, Ilham & Harjanti, Reslely. (2021). Formulation And Optimization Of Furosemide Snedds With Variation Concentration Of Tween 80 And PEG 400. Journal Of Fundamental And Applied Pharmaceutical Science.

Nastiti, C,M,R,R,; Ponto, T,; Abd, E,; Grice, J,E,; Benson, H,A,E,; Roberts, M,S, Topical Nano And Microemulsions For Skin Delivery, Pharmaceutics 2017, 9, 37.

Naz Z, Ahmad FJ, Curcumin-Loaded Colloidal Carrier System: Formulation Optimization, Mechanistic Insight, Ex Vivo And In Vivo Evaluation, Int J Nanomedicine, 2015 Jul 3;10:4293-307, Doi: 10,2147/IJN,S82788, PMID: 26170665; PMCID: PMC4498720.

Nazari-Vanani R, Moezi L, Heli H. In Vivo Evaluation Of A Self-Nanoemulsifying Drug Delivery System For Curcumin. Biomed Pharmacother. 2017 Apr;88:715-720. Doi: 10.1016/J.Biopha.2017.01.102. Epub 2017 Jan 30. PMID: 28152481.

Nirmalayanti, N. L. P. K. V. (2021). Screening of Various Types of Surfactants and Cosurfactants as a Basis for Selecting Nanoemulsion Formulations. Metta: Journal of Multidisciplinary Science, 1(3), 158–166.

Nurahmanto, D,, Mahrifah, I,R,, Aziz, R,F,N,I,, Rosyidi, V,A,, 2017, Formulation of Solid Dispersion Gel Preparation of Ibuprofen: Study of Gelling Agent and Penetration Enhancing Compounds, Jurnal Imah Manuntung, 3(1), 96-105.

Nurcholis, I,A,, Yusriadi, Sulastri, E,, 2018, Anti-inflammatory Activity of Pearl Grass Extract Gel (Ordelandia Corumbosa L, ) in Rats (Rattus Norvegicus L,) Induced by Carrageenan, Biocelebes, 12(2013), 88-97

P,M, Reddi, A Touch Of Turmeric: Examining An Ayurvedic Treasure, Adv, Anthropol, 03 (02) (2013) 91–95.

Park, K,, Yeo, Y,, Swarbrick, J, 2007, Microencapsulation Technology In: Encyclopedia Of Pharmaceutical Technology 3rd Edition, New York: Informa Healthcare USA, Inc,, P, 2315- 2325.

Pathan, M,, Zikriya, A,, & Quazi, A, (2012), Microemulsion: As Excellent Drug Delivery System, International Journal For Pharmaceutical Research Schola

Rachmawati, H,, Budiputra, D,K,, Mauludin, R,, 2015, Curcumin Nanoemulsion For Transdermal Application: Formulation And Evaluation, Drug Dev Ind Pharm 41, 560-566,

Rosita, N,, A’yunin, Q,, & Hendradi, E, (2019), Karakter Solid Lipid Nano Particle (SLN) – Ubiquinon (Q10) Dengan Beda Jenis Kosurfaktan: Poloxamer 188, Lesitin, Propilen Glikol, Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 6, 17–23,

Rowe, R,C,, Sheskey, P,J,, Quinn, M,E,, 2009 Handbook Of Pharmaceutical Exipients, Revue Des Nouvelles Technologies De I’ Information,

Sivaram AJ, Rajitha P, Maya S, Jayakumar R And Sabitha M, Nanogels For Delivery, Imaging And Therapy, Wiley Int Erdisciplinary Reviews: Nanomedicine And Nanobiotechnology, 2015;7(4):509-33,

Sonavane, G,, Tomoda, K,, Sano, A,, Oshima, H,, Terada, H,, Makino, K, (2008), In Vitro Permeation Of Gold Nanoparticle Through Rat Skin And Rat Intestine : Effect Of Particle Size,Colloids And Surface Biointerfaces 65,1 – 10

Su’aida, N,, Sari, D,, & Fitriana, M, (2017), Optimization Of Gel Preparation Of Ethyl Acetate Fraction Of Mangifera Fruit (Mangifera Casturi Kosterm,) With Combination Of Cmc-Na And Carbopol Bases Using Simplex Lattice Design Method, JCPS (Journal Of Current Pharmaceutical Sciences), 1(1), 19-24.

Suharsanti, R,, Astutiningsih, C,, & Susilowati, N, D, (2020), Curcumin Levels of Turmeric Rhizome Extract (Curcuma Domestica) by TLC Densitometry with Different Extraction Methods, Wiyata Journal: Science and Health Research, 7(2), 86-93.

Suhendri, Nirwana, & Irdoni, (2016), Synthesis of Environmentally Friendly Surfactant Methyl Ester Sulfonate From Palm Oil Methyl Ester Using Sodium Metabisulfite And Aluminum Oxide Catalyst, 1–8

Syaputri, F. N., Dan Patricia, V. M. (2019). Pengaruh Penambahan Emulgator Tween Dan Span Terhadap Stabilitas Krim. Journal Of Science, Technology And Entrepreneur. 1(2):140-146.

Tasmina Kanwal, Salim Saifullah, Jawad Ur Rehman, Muhammad Kawish, Anam Razzak, Rukesh Maharjan, Muhammad Imran, Imdad Ali, Talat Roome, Shabana Usman Simjee, Muhammad Raza Shah, Design Of Absorption Enhancer Containing Self-Nanoemulsifying Drug Delivery System (SNEDDS) For Curcumin Improved Anti-Cancer Activity And Oral Bioavailability, Journal Of Molecular Liquids, Volume 324, 2021, 114774, ISSN 0167-7322.

Tonnesen, H,H, And Karlsen, J,, 1985, Studies On Curcumin And Curcuminoids Alkaline Degradation Of Curcuming Z,Lebens, Unters, Forsch, 180 : 132- 134

Wang, Y,J,, Pan, M,H,, Cheng, A,L,, Lin, L,I,, Ho, Y,S,, Hsieh, C,Y,, Dan Lin, J,K,, 1996, Stability Of Curcumin In Buffer Solutions And Characterization Of Its Degradation Products, J, Pharm, Biomed, Anal, 15 (12):1867-1876,

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Published

2024-11-13

How to Cite

Kusumawati, M. A., Iswandi, I., & Kuncahyo, I. . (2024). Optimization and Characterization of Self Nano Emulsifying Drug Delivery System (SNEDDS) of Curcumin with D-Optimal Mixture Design Method. East Asian Journal of Multidisciplinary Research, 3(11), 5115–5132. https://doi.org/10.55927/eajmr.v3i11.12051